Sort   by:  
 Page size 
TranscriptomicsAdvancing systemic toxicity risk assessment: Evaluation of a NAM-based toolbox approach
High throughput transcriptomics using the TempO-Seq (TM) platform for dose response modelling of 3 different cell lines treated with multiple compounds as part of a study to generate a toolbox and workflow for non-animal safety assessments. The data generated here was produced as one part of a toolb...
ORGANISM(S): Homo sapiens 
2025-09-15 | E-MTAB-15266 | biostudies-arrayexpress
TranscriptomicsPlatelet Activating Factor Receptor and Innate Immunity
This data series contains spotted oligo microarray data from 10 different experiments using Agilent Rat v2 microarrays. This data is being made public in support of Fillon S et al. Journal of Immunology, (2006). Proinflammatory bacterial components are at least partially responsible for causing the ...
ORGANISM(S): Rattus norvegicus 
2010-07-01 | E-GEOD-5545 | biostudies-arrayexpress
TranscriptomicsBulk RNA-seq of immortalized N/TERT keratinocytes stimulated with IFNγ
Inflammasomes are multicomplex proteins which drive pro-inflammatory cytokine responses and pyroptosis in innate immunity. Of which, the NLRP3 inflammasome is the most extensively studied, especially in myeloid immune cells such as macrophages. Conversely, the regulation of NLRP3 in non-immune cell ...
ORGANISM(S): Homo sapiens 
2025-10-30 | E-MTAB-15754 | biostudies-arrayexpress
TranscriptomicsAre Non-animal Systemic Safety Assessments Protective: A Toolbox and Workflow
High throughput transcriptomics using the TempO-Seq (TM) platform for dose response modelling of 3 different cell lines treated with multiple compounds as part of a study to generate a toolbox and workflow for non-animal safety assessments. The data generated here was produced as one part of a toolb...
ORGANISM(S): Homo sapiens 
2025-09-15 | E-MTAB-15258 | biostudies-arrayexpress
GenomicsChIP-seq analysis of the cAMP binding protein (CRP) in Enteroaggregative Escherichia coli 042
ChIP-seq experiments were carried out in Enteroaggregative Escherichia coli 042. Wildtype 042 cells were grown to mid-log phase in LB medium, before being crosslinked with 1% formaldehyde and sonicated to lyse cells and shear DNA. Immunocomplexes were established using anti-FLAG antibodies. The immu...
ORGANISM(S): Escherichia coli 
2025-07-09 | E-MTAB-14748 | biostudies-arrayexpress
TranscriptomicsRNA-seq and genome-wide CRISPRi and Tn-seq analyses of BVL3572S-treated Mycobacterium tuberculosis H37Rv
(i) RNA-seq of M. tuberculosis H37Rv cultures grown in the presence of BVL3572S for 6 h compared to untreated controls. (ii) Genome-wide M. tuberculosis H37Rv CRISPRi libraries were grown in the presence of ATc for 5 days prior to drug exposure. Cultures were treated with sub-MIC BVL3572S concentra...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2026-04-20 | E-MTAB-16773 | biostudies-arrayexpress
GenomicsWhole genome sequencing of spontaneous resistant mutants of Mycobacterium tuberculosis H37Rv selectec in the presence of BVL3572S and amino acids
M. tuberculosis H37Rv cultures were exposed to BVL3572S in the absence or presence of L-histidine or L-alanine for at least 4 weeks. Individual colonies were picked and their genomic DNA extracted, indexed, and sequenced.
ORGANISM(S): Mycobacterium tuberculosis 
2026-06-03 | E-MTAB-17255 | biostudies-arrayexpress
TranscriptomicsAn Advancement in Developmental and Reproductive Toxicity (DART) Risk Assessment: Evaluation of a Bioactivity and Exposure-Based NAM Toolbox
High throughput transcriptomics using the TempO-Seq (TM) platform for dose response modelling of 3 different cell lines treated with multiple compounds as part of a study to generate a toolbox and workflow for non-animal safety assessments. The data generated here was produced as one part of a toolb...
ORGANISM(S): Homo sapiens 
2025-09-15 | E-MTAB-15274 | biostudies-arrayexpress
TranscriptomicsMitochondrial carrier SLC25A34 links clock, diet, and temperature control of adipocyte lipid cycling
BAT transcriptome from control and brown adipocyte-specific Rev-erbα/β double knockout mice housed at thermoneutrality or cold-challenged for 6 hours. Brown adipose tissue (BAT) samples were collected from control and brown adipocyte-specific Rev-erbα/β double knockout mice (Ucp1-Cre; Nr1d1/2 fl/fl)...
ORGANISM(S): Mus musculus 
2026-09-23 | E-MTAB-17580 | biostudies-arrayexpress
TranscriptomicsMitochondrial carrier SLC25A34 links clock, diet, and temperature control of adipocyte lipid cycling
Transcriptome from immortalized murine brown adipocytes BMC. Cells were transfected with siRNA construct #1 or construct #2 (pool) or non-targeting control on day 3 of differentiation and harvested on day 7 of differentiation.
ORGANISM(S): Mus musculus 
2026-09-23 | E-MTAB-17577 | biostudies-arrayexpress
Sort   by:  
 Page size