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ProteomicsInverse data-driven modelling and multiomics analysis reveals PHGDH as a metabolic signature of M2 macrophages
Activation of immune cells is accompanied by a metabolic reconfiguration of their cellular energy metabolism including shifts in glycolysis and mitochondrial respiration that critically regulate functional effector responses. However, while current mass spectrometry strategies identify overall or fl...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-26 | PXD010657 | Pride
Macrophages Metabolic modelling Metabolomics Biochemical jacobian Tor Tsc2 Serin pathway 
MetabolomicsNorbergenin prevents LPS-induced inflammatory responses in macrophages through inhibiting NFkB, MAPK and STAT3 activation and blocking metabolic reprogramming

Inflammation is thought to be a key cause of many chronic diseases and cancer. However, current therapeutic agents to control inflammation have limited long-term use potential due to various side-effects. This study aimed to examine norbergenin, a constituent of traditional anti-inflammatory reci...

2023-04-06 | MTBLS7127 | MetaboLights
MetabolomicsMetabolic responses of rice cultivars with different tolerance to combined heat and drought stress under field conditions
Rice is susceptible to both heat and drought stress, in particular during flowering and grain filling, when both grain yield and quality may be severely compromised. However, under field conditions, these two stresses rarely occur separately. Under well-watered conditions, plants avoid heat stress b...
2019-04-25 | MTBLS801 | MetaboLights
MetabolomicsBranched-chain ketoacids derived from cancer cells modulate macrophage polarization and metabolic reprogramming

Macrophages are prominent immune cells in the tumor microenvironment that can be educated into pro-tumoral phenotype by tumor cells to favor tumor growth and metastasis. The mechanisms that mediate a mutualistic relationship between tumor cells and macrophages remain poorly characterized. Here, w...

2022-10-03 | MTBLS4497 | MetaboLights
ProteomicsProteomics and comparative genomics of Nitrososphaera viennensis
Ammonia-oxidizing archaea (AOA) are among the most abundant microorganisms and key players in the global nitrogen and carbon cycles. They share a common energy metabolism but represent a heterogeneous group with respect to their environmental distri- bution and adaptions, growth requirements, and ge...
ORGANISM(S): Nitrososphaera viennensis EN76 
2017-05-03 | PXD005297 | Pride
Ammonia oxidation Biofilm Archaea 
MetabolomicsDissecting Metabolism of Leaf Nodules in Ardisia crenata and Psychotria punctata
Root-microbe interaction and its specialized root nodule structures and functions are well studied. In contrast, leaf nodules harboring microbial endophytes in special glandular leaf structures have only recently gained increased interest as plant-microbe phyllosphere interactions. Here, we applied ...
2021-08-26 | MTBLS2870 | MetaboLights
ProteomicsClusia genomes shed light on the evolution and diversity of CAM physiotypes
225 years ago, Alexander von Humboldt documented his first observations of a peculiar phenomenon in Clusia rosea (Clusiaceae), the first tree known to perform crassulacean acid metabolism (CAM). Since then, the photosynthetic and ecophysiological plasticity of Clusia species have captivated the mind...
ORGANISM(S): Clusia minor Clusia rosea Clusia major 
2026-03-12 | PXD061385 | Pride
Diploidization Cam plant evolution Clusia Polyploidy 
ProteomicsGmax - Root nodule, iBAQ (Preineretal,frontplantsci2019)
abundance based on iBAQ, Interaction consistency score: 7.5, Coverage: 7
ORGANISM(S): 3847 
2019-00-00 | 381737638 | PAXDB
ProteomicsGmax - Shoot, iBAQ (Preineretal,frontplantsci2019)
abundance based on iBAQ, Interaction consistency score: 7.6, Coverage: 7
ORGANISM(S): 3847 
2019-00-00 | 2125262930 | PAXDB
ProteomicsGmax - Root nodule, iBAQ (Preineretal,frontplantsci2019)
abundance based on iBAQ, Interaction consistency score: 9.3, Coverage: 7
ORGANISM(S): 3847 
2019-00-00 | 1409813430 | PAXDB
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