Sort   by:  
 Page size 
TranscriptomicsGene expression profiling of L-540 Hodgkin lymphoma cell line after in vitro and in vivo treatment with Givinostat in combination with Sorafenib
Relapsed/refractory Hodgkin lymphoma (HL) is an unmet medical need requiring new therapeutic options. Interactions between the histone deacetylase inhibitor Givinostat and the RAF/MEK/ERK inhibitor Sorafenib were examined in HDLM-2 and L-540 HL cell lines. Exposure to Givinostat/Sorafenib induced a ...
ORGANISM(S): Homo sapiens 
2015-03-01 | E-GEOD-65483 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of HDLM-2 Hodgkin lymphoma cell line after in vitro and in vivo treatment with Givinostat in combination with Sorafenib
Relapsed/refractory Hodgkin lymphoma (HL) is an unmet medical need requiring new therapeutic options. Interactions between the histone deacetylase inhibitor Givinostat and the RAF/MEK/ERK inhibitor Sorafenib were examined in HDLM-2 and L-540 HL cell lines. Exposure to Givinostat/Sorafenib induced a ...
ORGANISM(S): Homo sapiens 
2015-03-01 | E-GEOD-65479 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of L-540 Hodgkin lymphoma cell line after in vitro and in vivo treatment with perifosine in combination with sorafenib
Three HL cell lines (HD-MyZ, L-540 and HDLM-2) were used to investigate the effects of perifosine and sorafenib using in vitro assays analyzing cell growth, cell cycle distribution, gene expression profiling (GEP), and apoptosis. Western blotting (WB) experiments were performed to determine whether ...
ORGANISM(S): Homo sapiens 
2015-01-29 | E-GEOD-31059 | biostudies-arrayexpress
TranscriptomicsL-plastin Ser5 phosphorylation via RSKs, downstream effectors of the MAPK/ERK pathway, in (breast) cancer cells (and in vitro)
Deregulated cell migration and invasion, which are hallmarks of metastatic cancer cells, are correlated to structural and functional alterations of the actin cytoskeleton associated to a large panel of actin-binding proteins. Among these, the actin-bundling protein L-plastin, initially detected in l...
ORGANISM(S): Homo sapiens 
2016-03-26 | E-MTAB-3487 | biostudies-arrayexpress
TranscriptomicsEnvironmentally Induced Transgenerational Epigenetic Reprogramming of Primordial Germ Cells and Subsequent Germline
A number of environmental factors (e.g. toxicants) have been shown to promote the epigenetic transgenerational inheritance of disease and phenotypic variation. Transgenerational inheritance requires the germline transmission of altered epigenetic information between generations in the absence of dir...
ORGANISM(S): Rattus norvegicus 
2013-01-17 | E-GEOD-43559 | biostudies-arrayexpress
ProteomicsIdentification of Mitogen-Activated Protein Kinase Phosphatase-1 (MKP-1) protein partners using Tandem Affinity Purification and Mass Spectrometry
According to the World Health Organization Report, depressive disorders affect about 10% of the population. The molecular mechanism of the pathogenesis of depression is still not well understood. The new findings point to phosphatases as potential targets for effective depression therapy. The aim of...
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) 
2023-01-19 | MSV000091093 | MassIVE
ProteomicsProximity proteomics identifies PAK4 as a component of Afadin–Nectin junctions.
Human PAK4 is an ubiquitously expressed p21-activated kinase which acts downstream of Cdc42. Since PAK4 is demonstrably enriched in cell-cell junctions, we probed the local protein environment around the kinase with a view to understanding its location and substrates. In U2OS cells expressing PAK4-B...
ORGANISM(S): Homo sapiens (Human) 
2021-11-30 | PXD024464 | Pride
Lzts2 Pak4 Cdc42 Bioid Epithelial cells Protein kinase Cell junctions 
TranscriptomicsDeterminants of sensitivity to DZNep induced apoptosis in multiple myeloma cells
The 3-Deazaneplanocin A (DZNep), one of S-adenosylhomocysteine (AdoHcy) hydrolase inhibitors, has shown antitumor activities in a broad range of solid tumors and acute myeloid leukemia. Here, we examined its effects on multiple myeloma (MM) cells and found that, at 500 nM, it potently inhibited grow...
ORGANISM(S): Homo sapiens 
2011-07-04 | E-GEOD-26921 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of HD-MyZ Hodgkin lymphoma cell line after in vitro and in vivo treatment with perifosine in combination with sorafenib
Three HL cell lines (HD-MyZ, L-540 and HDLM-2) were used to investigate the effects of perifosine and sorafenib using in vitro assays analyzing cell growth, cell cycle distribution, gene expression profiling (GEP), and apoptosis. Western blotting (WB) experiments were performed to determine whether ...
ORGANISM(S): Homo sapiens 
2015-01-29 | E-GEOD-31058 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of HDLM-2 Hodgkin lymphoma cell line after in vitro and in vivo treatment with perifosine in combination with sorafenib
Three HL cell lines (HD-MyZ, L-540 and HDLM-2) were used to investigate the effects of perifosine and sorafenib using in vitro assays analyzing cell growth, cell cycle distribution, gene expression profiling (GEP), and apoptosis. Western blotting (WB) experiments were performed to determine whether ...
ORGANISM(S): Homo sapiens 
2015-01-29 | E-GEOD-31057 | biostudies-arrayexpress
Sort   by:  
 Page size