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TranscriptomicsExpression data from murine cardiac tissue
Gender dimorphism exists in the physiological response to diet and other environmental factors. Trans-hydrogenated fatty acid (TFA) intake is associated with an increase in coronary heart disease (CHD), and gender differences in the incidence of CHD are well documented. Neonatal administration of M...
ORGANISM(S): Mus musculus 
2011-12-31 | E-GEOD-22881 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat resistance artery in 2 models of hypertension
We investigated morphometric structure and gene expression by microarray analysis in a small diameter artery, branch of the saphenous artery (a resistance artery), in representative models of renin-angiotensin system (RAS)-dependent and glucocorticoid hypertension, using the spontaneously hypertensi...
ORGANISM(S): Rattus norvegicus 
2008-06-15 | E-GEOD-8051 | biostudies-arrayexpress
ProteomicsMultiomic analysis of PI3K in Atrial Myopathy
Here, we undertook comprehensive physiological and molecular analyses in cardiac-specific transgenic mice with increased or decreased PI3K to assess the dose response impact of directly regulating PI3K. Elevated PI3K was associated with a dose-dependent increase in heart size, and preserved/enhanced...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
MSV000092855 | MassIVE
TranscriptomicsRNA profiling in lungs of WT and HGF transgenic mice with or without exposure to carcinogen
The hepatocyte growth factor (HGF)/c-Met signaling pathway is known to mediate vascularization. We have previously demonstrated that expression of a human HGF transgene in the small airways produced mice (HGF TG) that were more susceptible to the tobacco carcinogen, 4-(methylnitrosamino)-1-(3-pyridy...
ORGANISM(S): Mus musculus 
2010-12-31 | E-GEOD-20468 | biostudies-arrayexpress
TranscriptomicsExpression data from feline liver tissue
This study looks at the effect of dietary manipulation on the development of hepatic steatosis and changes in hepatic gene expression in a feline model. We used microarray analysis to examine changes in hepatic gene transcription in response to Trans fat, High Fructose Corn Syrup (HFCS) and/or Mono...
ORGANISM(S): Felis catus 
2014-06-11 | E-GEOD-30040 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse macrophaes and mast cells from Pac1+/+ versus Pac1-/- animals
This SuperSeries is composed of the following subset Series:; GSE3993: Pac1+/+ versus Pac1-/- TG-macrophages_LPS 6h; GSE3994: Pac1+/+ versus Pac1-/- BMMCs_IgE-DNP 2 h Experiment Overall Design: Refer to individual Series
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-4014 | biostudies-arrayexpress
TranscriptomicsGNF mouse atlas_macrophages
Monocytes and macrophages express an extensive repertoire of G Protein-Coupled Receptors (GPCRs) that regulate inflammation and immunity. In this study we performed a systematic microarray analysis of GPCR expression in primary mouse tissues to identify family members that are either enriched in mac...
ORGANISM(S): Mus musculus 
2008-05-05 | E-GEOD-11339 | biostudies-arrayexpress
TranscriptomicsInhibition of astroglial NF-kB regulates oligogenesis following spinal cord injury.
Astrocytes are taking the center stage in neurotrauma and neurological disease as they appear to play a dominant role in the inflammatory processes associated with these conditions. Previously, we reported that inhibiting nuclear factor kappa B (NF-kB) activation in astrocytes, by using a transgenic...
ORGANISM(S): Mus musculus 
2013-09-01 | E-GEOD-46695 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of S. cerevisiae cultures grown under low shear-modeled microgravity
The goal of this study was to assess whether low shear-modeled microgravity (LSMMG) effects yeast ,genomic expression patterns using the powerful tool of whole genome microarray hybridization. We determined ,changes in the yeast model organism, Saccharomyces cerevisisae, when grown in LSMMG using th...
ORGANISM(S): Saccharomyces cerevisiae 
2007-07-07 | E-GEOD-4136 | biostudies-arrayexpress
TranscriptomicsRNAseq analysis of colon and ileum tissue from naive wild type, MR1-/- and IL-17A-/- mice
Determination of differentially expressed genes in the proximal colon and distal ileum tissue in MR1 and IL-17A deficiency at steady-state. Tissue from naïve mice was harvested, total RNA extracted and subjected to RNASeq analysis.
ORGANISM(S): Mus musculus 
2018-03-31 | E-MTAB-6547 | biostudies-arrayexpress
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