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ProteomicsComprehensive 2D-LC/MS/MS profile of normal human urinary metabolome
A comprehensivemetabolomics profile of normal human urine
ORGANISM(S): Homo Sapiens 
2022-07-22 | PXD035515 |
MetabolomicsExploring the gut microbiome and serum metabolome interplay in non-functioning pituitary neuroendocrine tumors.

The gut microbiome has emerged as a potential factor in cancer pathogenesis, but its role in non-functioning pituitary neuroendocrine tumors (NF-PitNETs) remains unclear. This study aimed to elucidate gut microbiome and metabolomic alterations in NF-PitNETs by comparing microbial diversity, patho...

2025-06-16 | MTBLS12328 | MetaboLights
ProteomicsFree rather than total iron content is critically linked to the Fur physiology in Shewanella oneidensis
Ferric uptake regulator (Fur) is a transcriptional regulator playing a central role in iron homeostasis of many bacteria and Fur inactivation commonly results in pleiotropic phenotypes. In Shewanella oneidensis, a representative of dissimilatory metal-reducing -proteobacteria capable of respiring a...
ORGANISM(S): Shewanella Oneidensis Mr-1 
2020-09-29 | PXD021732 |
ProteomicsQuantitative proteomic analysis of outer membrane vesicles from Fusobacterium nucleatum in the cancer environment
At present, the function of Fusobacterium nucleosocci outer membrane vesicles under normal intestinal environmental pH conditions has been mainly studied, but there are few studies related to the function of Fusobacterium nucleosius outer membrane vesicles under cancer microenvironment pH conditions...
ORGANISM(S): Fusobacterium Nucleatum Subsp. Vincentii 
2022-10-18 | PXD037520 |
ProteomicsSIRT3 acts as delactylase to suppress hepatocellular carcinoma development
Our integrative studies characterized SIRT3 as a delactylase to suppress HCC development, and the activation of SIRT3 might be a promising therapeutic mean for HCC.
ORGANISM(S): Homo Sapiens 
2023-01-03 | PXD039202 |
ProteomicsSIRT2 regulates extracellular vesicle-mediated liver-bone communication
The interplay between liver and bone metabolism remains largely uncharacterized. Here, we uncover a mechanism of liver-bone crosstalk regulated by hepatocyte SIRT2. We demonstrate that hepatocyte SIRT2 expression is increased in aged mice and elderly humans. Liver-specific SIRT2 deficiency inhibits ...
ORGANISM(S): Mus Musculus 
2023-03-27 | PXD041145 |
ProteomicsIntegrated proteomic and transcriptomic analyses reveal the roles of Brucella BI-1 in cell division and membrane homeostasis of Brucella suis S2
To explore the role of Brucella BI-1 in Brucella suis S2, we constructed the Brucella BI-1 deletion mutant strain and its complementary strain. We then determined the effect of Brucella BI-1 deletion on the physiological characteristics of Brucella suis S2 and revealed them via integrated transcript...
ORGANISM(S): Brucella Suis Bv. 1 Str. S2 
2020-11-13 | PXD022537 |
ProteomicsGlobal identification ofphospho-dependent SCF ubiquitin ligase substrate reveal a role of ERK-FBXO22-BAG3 axis in tumorigenesis
293T cells were cultured in SILAC medium. Heavy group was labeled with K6&R10. Light group was labeled with K0&R0. In light group, cells were treated with MLN4924. In heavy group, cells were treated with DMSO. Then cells were lysed, mixed and tryptic digested. Peptide mixture was subjected to phosph...
ORGANISM(S): Homo Sapiens 
2021-06-29 | PXD027020 |
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