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UnknownIntegrated transcriptome and metabolome analysis of melanin-related genes and metabolites in Muchuan Black Bones Chickens.
Not available
S-EPMC12752978 | biostudies-literature
GenomicsNational Heart Lung and Blood Institute Exome sequencing in SCID

Analysis of the molecular etiologies of severe combined immunodeficiency (SCID) has led to important insights into the control of immune cell development. Most cases of SCID result from either X-linked or autosomal recessive inheritance of mutations in a known causative gene. However, in some cas...

phs000479.v1.p1 | EGA
ProteomicsTreachery of hepatic protector triggers Notch signaling to promote hepatocyte-originated cholangiocarcinoma
Here, we found mesencephalic astrocyte-derived neurotrophic factor (MANF), a hepatic protector, was upregulated in human ICC tissues and sleeping beauty transposon (SBT) or thioacetamide (TAA)-induced mice ICC tissues. We verified the oncogenic role of MANF in ICC using cell lines overexpressing/kno...
ORGANISM(S): Homo sapiens (Human) 
2025-08-25 | PXD048451 | Pride
Hepatocytes Ip-ms Hucct1 Notch Cholangiocarcinoma Ck19 
UnknownEfficacy and Tolerability of First-Line Cetuximab Plus Leucovorin, Fluorouracil, and Oxaliplatin (FOLFOX-4) Versus FOLFOX-4 in Patients With RAS Wild-Type Metastatic Colorectal Cancer: The Open-Label, Randomized, Phase III TAILOR Trial.
Not available
S-EPMC6324088 | biostudies-literature
TranscriptomicsMolecular basis for chromatin binding and regulation of MLL5
The human mixed lineage leukemia 5 (MLL5) protein mediates hematopoietic cell homeostasis, cell cycle and survival, however, the molecular basis underlying MLL5 activities remains unknown. Here, we show that MLL5 is recruited to gene-rich euchromatic regions via the interaction of its PHD finger wit...
ORGANISM(S): Mus musculus 
2013-07-01 | E-GEOD-47100 | biostudies-arrayexpress
ProteomicsProteomic Antibacterial Characterization of Flavonoid Xanthohumol and probiotic Clostridium butyricum on Pathogenic Clostridioides difficile
In this study, we evaluated the antimicrobial properties of XN and C. butyricum culture supernatant (CBs) against C. difficile, focusing on their ability to reduce C. difficile adhesion, inhibit growth, and restrict toxin production. Using a dextran sulfate sodium (DSS)-induced Caco-2 intestinal epi...
ORGANISM(S): Clostridioides Difficile 70-100-2010 Clostridioides Difficile Atcc 9689 = Dsm 1296 
2025-10-21 | PXD069714 |
ProteomicsProteomic investigations of transcription factors critical in geniposide-mediated suppression of alcoholic steatosis and in overdose induced hepatotoxicity on liver
Geniposide mediated therapeutic effects and overdose-induced hepatotoxicity
ORGANISM(S): Rattus Rattus 
2019-08-12 | PXD014996 |
ProteomicsNovel Molecular Subgroups of Intrahepatic Cholangiocarcinoma Discovered by Single-Cell RNA Sequencing-Assisted Multi-Omics Analysis
Intrahepatic cholangiocarcinoma (ICC) is a relatively rare but highly aggressive tumour type that responds poorly to chemotherapy and immunotherapy. Comprehensive molecular characterization of ICC is essential for the development of novel therapeutics. Here, we constructed two independent cohorts fr...
ORGANISM(S): Homo Sapiens 
2022-04-13 | PXD033206 |
ProteomicsProteomic profiling reveals the impact of surface functionalization on the protein corona formed on superparamagnetic iron oxide nanoparticles
The protein corona formed on the surface of nanomaterials is critical to understanding their biological behavior, as it is regulated by both the physicochemical properties of the nanomaterials and the physiological environment. The interplay between material synthesis characteristics, protein corona...
ORGANISM(S): Homo Sapiens 
2024-10-14 | PXD056769 |
ProteomicsPick-up single-cell proteomic analysis for quantifying up to 3000 proteins in a tumor cell
The shotgun proteomic analysis is currently the most promising single-cell protein sequencing technology, however its identification level of ~1000 proteins per cell is still insufficient for practical applications. Here, we develop a pick-up single-cell proteomic analysis (PiSPA) workflow to achiev...
ORGANISM(S): Homo Sapiens 
2023-10-30 | PXD041966 |
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