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ProteomicsIdentification of a 144-amino-acid Scaffold Protein for Extracellular Vesicle Engineering
Extracellular vesicles (EVs) have emerged as promising drug-delivery vehicles. Genetic engineering of a membrane-bound, EV-sorting scaffold protein empowers these cell-borne nanosized vesicles by installing targeting moieties on the surface and enriching therapeutic cargo in the lumen. However, the ...
ORGANISM(S): Homo sapiens (Human) 
2026-04-27 | PXD057965 | Pride
Expi293f-evs Lc-s/ms 
ProteomicsSilicon-rhodamine-enabled Identification (SeeID) for Near-Infrared Light Controlled Proximity Labeling In Vitro and In Vivo
Advancement in fluorescence imaging techniques enables the study of protein dynamics and localization with unprecedented spatiotemporal resolution. However, current imaging tools are unable to elucidate dynamic protein interactomes underlying imaging observations. In contrast, proteomics tools such ...
ORGANISM(S): Homo Sapiens Mus Musculus 
PXD067243 |
ProteomicsLactylation of NAT10 promotes N4‐acetylcytidine modification on tRNASer-CGA-1-1 to boost oncogenic DNA virus KSHV reactivation
N4-acetylcytidine (ac4C), a conserved but recently rediscovered RNA modification on tRNAs, rRNAs and mRNAs, is catalyzed by N-acetyltransferase 10 (NAT10). Lysine acylation is a ubiquitous protein modification that controls protein functions. Our latest study demonstrates a NAT10-dependent ac4C modi...
ORGANISM(S): Homo Sapiens 
PXD049447 |
ProteomicsPlasma proteomic and metabolomic signatures of B-ALL patients during CAR-T cell therapy
The study aimed to assess plasma proteomic and metabolomic profiling in patients with B-ALL during humanized anti-CD19-CAR-T cell therapy
ORGANISM(S): Homo Sapiens 
2023-02-24 | PXD040366 |
ProteomicsPlasma proteomic and metabolomic signatures of B-ALL patients during CAR-T cell therapy-2
The study aimed to assess plasma proteomic and metabolomic profiling in patients with B-ALL during humanized anti-CD19-CAR-T cell therapy
ORGANISM(S): Homo Sapiens 
2023-02-27 | PXD040411 |
ProteomicsA prokaryotic E2 enzyme imitates the ubiquitin pathway to regulate the antiviral cGAS
The cyclic oligonucleotide-based anti-phage signalling system (CBASS) is a typeof innate prokaryotic immune system. Composed of a cyclic GMP-AMP synthase (cGAS) and CBASS-associated proteins, CBASS utilizes cyclic oligonucleotides to activate antiviral immunity. One major class of CBASS contains a h...
ORGANISM(S): Serratia Marcescens Lct-sm213 
2024-02-27 | PXD050178 |
ProteomicsA proximity labeling map of SARS-CoV-2 and human
The global epidemic caused by the coronavirus severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has resulted in the infection of over 200 million people. To extend the knowledge of interactions between SARS-CoV-2 and humans, we systematically investigate the interactome of 29 viral protei...
ORGANISM(S): Homo Sapiens 
2022-01-06 | PXD022086 |
ProteomicsSS18 regulates pluripotent-somatic transition through phase separation
The transition from pluripotent to somatic states marks a critical event in mammalian development, but remains largely unresolved. Here we report the identification of SS18 as a regulator for pluripotent to somatic transition or PST by CRISPR-based whole genome screens. Mechanistically, SS18 forms m...
ORGANISM(S): Mus Musculus 
PXD026208 |
UnknownFine mapping of genetic variants in BIN1, CLU, CR1 and PICALM for association with cerebrospinal fluid biomarkers for Alzheimer's disease.
Not available
S-EPMC3036586 | biostudies-literature
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