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ProteomicsInteraction networks of Weibel-Palade body regulators syntaxin-3 and syntaxin binding protein 5 in endothelial cells
The endothelium stores the hemostatic protein Von Willebrand factor (VWF) in endothelial storage organelles called Weibel-Palade bodies (WPBs). During maturation, WPBs recruit a complex of Rab GTPases and effectors that associate with components of the SNARE machinery that control WPB exocytosis. Re...
ORGANISM(S): Homo sapiens (Human) 
2023-01-06 | PXD012809 | Pride
Weibel-palade body  snare protein  syntaxin  protein-protein interactions 
ProteomicsSyntaxin 5 determines Weibel-Palade body size and Von Willebrand factor secretion by controlling Golgi architecture
Abstract Von Willebrand factor (VWF) is a multimeric hemostatic protein primarily synthesized in endothelial cells (ECs). VWF is stored in endothelial storage organelles, the Weibel-Palade bodies (WPBs), whose biogenesis strongly depends on VWF anterograde trafficking and Golgi architecture. Elongat...
ORGANISM(S): Homo sapiens (Human) 
2022-01-27 | PXD027516 | Pride
Human Endothelial cells Weibel-palade bodies Von willebrand factor 
ProteomicsSyntaxin-3 is a Weibel-Palade body localized SNARE protein that regulates Von Willebrand factor secretion from endothelial cells
Endothelial cells store von Willebrand factor (VWF) in rod-shaped secretory organelles, called Weibel-Palade bodies (WPBs). WPB exocytosis is coordinated by a complex network of Rab GTPases, Rab-effectors and SNARE proteins. We have previously identified STXBP1 as the link between the Rab27A-Slp4-a ...
ORGANISM(S): Homo sapiens (Human) 
2018-07-04 | PXD006176 | Pride
Endothelial cells Proteomics Weibel-palade body Snare machinery Syntaxin-3 Von willebrand factor 
ProteomicsDefective AP-3-dependent VAMP8 trafficking impairs Weibel-Palade body exocytosis in Hermansky-Pudlak Syndrome type 2 blood outgrowth endothelial cells.
Weibel-Palade bodies (WPBs) are endothelial secretory organelles that contain VWF, P-selectin and CD63. Release of VWF from WPBs is crucial for platelet adhesion during primary hemostasis. Endosomal trafficking of proteins like CD63 to WPBs during maturation is dependent on the AP-3 complex. Mutatio...
ORGANISM(S): Homo sapiens (Human) 
2019-01-31 | PXD011294 | Pride
Endothelial cells Weibel-palade bodies Hps2 Ap3 complex 
UnknownRalB uncoupled exocyst mediates endothelial Weibel-Palade body exocytosis.
Not available
S-EPMC11429928 | biostudies-literature
UnknownSphingosine 1-phosphate activates Weibel-Palade body exocytosis.
Not available
S-EPMC509226 | biostudies-literature
UnknownChromogranin A regulates renal function by triggering Weibel-Palade body exocytosis.
Not available
S-EPMC2709688 | biostudies-literature
UnknownTowards the imaging of Weibel-Palade body biogenesis by serial block face-scanning electron microscopy.
Not available
S-EPMC4670698 | biostudies-literature
Unknown2-Chlorofatty acids induce Weibel-Palade body mobilization.
Not available
S-EPMC5748502 | biostudies-literature
UnknownPlasma membrane phosphatidylinositol (4,5)-bisphosphate promotes Weibel-Palade body exocytosis.
Not available
S-EPMC7442956 | biostudies-literature
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