Sort   by:  
 Page size 
ProteomicsEngineering of human myotubes towards a mature metabolic and contractile phenotype
Skeletal muscle mediates the beneficial effects of exercise, thereby improving insulin sensitivity and reducing the risk for type 2 diabetes. Current skeletal-muscle-models in vitro are incapable of fully recapitulating its physiological functions especially regarding exercise. Supplementation of IG...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD043200 | Pride
Myotubes Mass spectrometry Igf Immunohistochemistry 
TranscriptomicsCytokines dominate the secretome of primary human myotubes in an in vitro exercise model
Muscle contraction during exercise is the major stimulus for the release of peptides and proteins (myokines) that are supposed to take part in the benefical adaptation to exercise. We hypothesize that application of an in vitro exercise stimulus as electric pulse stimulation (EPS) to human myotubes ...
ORGANISM(S): Homo sapiens 
2013-10-09 | E-GEOD-44051 | biostudies-arrayexpress
ProteomicsProteomic profiling on sex-specific changes on skeletal muscle after exercise
Biological sex-based differences are reported for aerobic capacity, exercise performance, skeletal muscle mass and fiber-type composition. We aimed to provide a yet missing comprehensive picture of molecular differences between female and male skeletal muscle before and during an 8-week exercise int...
ORGANISM(S): Homo sapiens (Human) 
2025-09-02 | PXD058700 | Pride
Sex Skeletal muscle Lc-msms 
TranscriptomicsAnnotating the secretome of mature primary human muscle cells
The Skeletal muscle is a metabolic active tissue that secretes various proteins. These so called myokines act auto-, para- and endocrine affecting muscle physiology and exert systemic effects on other tissues and organs. Myokines are also described to play a crucial role in the pathophysiology of me...
ORGANISM(S): Homo sapiens 
2013-12-03 | E-GEOD-45473 | biostudies-arrayexpress
TranscriptomicsEffect of type 2 diabetes on transcriptional signatures during exercise and recovery
We performed gene expression microarray analysis of skeletal muscle biopsies from normal glucose tolerant subjects and type 2 diabetes subjects obtained during a 60 min bicycle ergometer exercise and the 180 min of recovery phase We analysed skeletal mucle biopsies from patients with T2D and from co...
ORGANISM(S): Homo sapiens 
2015-07-03 | E-GEOD-59363 | biostudies-arrayexpress
TranscriptomicsTGFβ contributes to impaired exercise response by suppression of mitochondrial key regulators in skeletal muscle
substantial number of people at risk to develop type 2 diabetes could not improve insulin sensitivity by physical training intervention. We studied the mechanisms of this impaired exercise response in 20 middle-aged individuals who performed a controlled eight weeks cycling and walking training at 8...
ORGANISM(S): Homo sapiens 
2016-06-29 | E-GEOD-72462 | biostudies-arrayexpress
Sort   by:  
 Page size