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TranscriptomicsADH1 deletion cells upon growth on alternative carbon sources; Steady-state grown cells upon environmental perturbations
Cells must adjust their gene expression in order to compete in a constantly changing environment. Two alternative strategies could in principle ensure optimal coordination of gene expression with physiological requirement. First, the internal physiological state itself could feedback to regulated ge...
ORGANISM(S): Saccharomyces cerevisiae 
2007-02-28 | E-GEOD-6302 | biostudies-arrayexpress
TranscriptomicsInferring gene regulatory logic from high-throughput measurements of thousands of systematically designed promoters
Despite extensive research, our understanding of the rules according to which cis-regulatory sequences are converted into gene expression is limited We devised a method for obtaining parallel, highly accurate gene expression measurements from thousands of designed promoters and applied it to measure...
ORGANISM(S): Saccharomyces cerevisiae 
2012-05-20 | E-GEOD-37851 | biostudies-arrayexpress
TranscriptomicsUnraveling determinants of transcription factor binding outside the core binding site
Binding of transcription factors (TFs) to regulatory sequences is a pivotal step in the control of gene expression. Despite many advances in the characterization of sequence motifs recognized by TFs, our ability to quantitatively predict TF binding to different regulatory sequences is still limited....
ORGANISM(S): synthetic construct 
2015-03-04 | E-GEOD-66143 | biostudies-arrayexpress
TranscriptomicsMassively parallel interrogation of the effects of gene expression levels on cellular fitness
Data of gene expression levels across individuals, cell types, and disease states is rapidly expanding, yet we have limited understanding of how expression levels impact cellular and organismal phenotypes. Here, we present a massively parallel system for assaying the effect of gene expression levels...
ORGANISM(S): Saccharomyces cerevisiae 
2016-08-25 | E-GEOD-83936 | biostudies-arrayexpress
TranscriptomicsSystematic discovery of cap-independent translation sequences in human and viral genomesÂ
To investigate gene specificity at the level of translation in both the human genome and viruses we devised a high-throughput bicistronic assay to quantify cap-independent translation. We uncover thousands of novel cap-independent translation sequences and provide insights on the landscape of transl...
ORGANISM(S): synthetic construct 
2015-10-23 | E-GEOD-74277 | biostudies-arrayexpress
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