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TranscriptomicsGene expression in primary human B cells sorted according to IL-10 secretion or not after 2 days of activation.
To determine characterize human B cells that express IL-10 on a molecular level, we compared the global gene expression of primary CD19pos B cells secreting IL-10 or not, upon activation with anti-CD40, IL-4 and CpG for 2 days. Human B cells from healthy donors were sorted according to CD19 expressi...
ORGANISM(S): Homo sapiens 
2014-03-24 | E-GEOD-49853 | biostudies-arrayexpress
TranscriptomicsGene expression of resting memory, resting naive and in vitro activated memory CD8+CD127+ T cells from spleen and bone marrow (BM)
To understand differences between resting and activated memory CD8+ T cells, we compared the global gene expression of ex vivo isolated naive and spleen and BM memory cells to in vitro activated spleen and BM memory cells. Single cell suspension from the spleen and bones of aged C57BL/6 mice were pr...
ORGANISM(S): Mus musculus 
2015-02-05 | E-GEOD-62691 | biostudies-arrayexpress
TranscriptomicsGene expression of in vitro cultivated preB cells before and after 8, 16 and 24 hours induction of miR-221
PreB cells were analyzed for differences in gene expression before and after the overexpression of miR-221. In order to dissect possible targets for the miR-221, gene expression profiles of preB cells un-induced or induced for the miR-221 expression after 8, 16 and 24 hours were compared. All induct...
ORGANISM(S): Mus musculus 
2013-06-05 | E-GEOD-47643 | biostudies-arrayexpress
TranscriptomicsRsk2 controls synovial fibroblast hyperplasia and the course of arthritis.
To understand differences in the pathogenesis of synovial hyperplasia during TNF-induced arthritis, we compared the global gene expression of hTNFtg and hTNFtg;Rsk2-/y primary synovial fibroblasts. Murine fibroblast-like synoviocytes (FLS) were isolated from the hind paws of hTNFtg and hTNFtg;Rsk2-/...
ORGANISM(S): Mus musculus 
2014-12-04 | E-GEOD-52992 | biostudies-arrayexpress
TranscriptomicsIdentification of a CD271-associated signaling network in human malignant melanoma cells
Background: Large-scale genomic analyses of patient cohorts have revealed extensive heterogeneity between individual tumors, contributing to treatment failure and drug resistance. In malignant melanoma, heterogeneity is thought to arise as a consequence of the differentiation of melanoma-initiating ...
ORGANISM(S): Homo sapiens 
2013-11-19 | E-GEOD-52456 | biostudies-arrayexpress
TranscriptomicsInfluence of isolation procedure and storage condition on the ex vivo gene expression pattern in peripheral human effector/memory T helper lymphocytes
Gene expression profiling of cells isolated ex vivo is a unique tool to assess gene expression in vivo. Exemplified for CD4+CD45RO+ effector/memory T helper (T E/M) lymphocytes of human peripheral blood, we have analyzed different isolation procedures and storage conditions for the introduction of b...
ORGANISM(S): Homo sapiens 
2014-03-24 | E-GEOD-54247 | biostudies-arrayexpress
TranscriptomicsGlobal regulatory networks active in Pseudomonas syringae B728 during leaf colonization and in response to target environmental stresses: the GacS, SalA, RetS, AlgU, HrpL, RpoN, RpoS, AhlR and AefR regulons
The plant pathogen Pseudomonas syringae pv. syringae B728a grows and survives on leaf surfaces and in the leaf apoplast of its host, bean. Global transcriptome profiling was used to understand the contribution of distinct regulators to B728a fitness and pathogenicity. We performed a transcriptome a...
ORGANISM(S): Pseudomonas syringae 
2014-09-01 | E-GEOD-59273 | biostudies-arrayexpress
TranscriptomicsGene expression of T follicular helper (TFH) cells 6 h after ICOS-L blockade
The maintenance of the TFH phenotype depends on continuous signals via ICOS. For a global assessment of differences in gene expression after interruption of the ICOS pathway a genome wide transcriptome analysis was performed. We used the OT-II adoptive transfer system to isolate antigen-specific TFH...
ORGANISM(S): Mus musculus 
2015-01-19 | E-GEOD-49314 | biostudies-arrayexpress
TranscriptomicsGene expression of 4, 5, and 6 days differentiated Flk1+ WT ES cells, and of 6 days differentiated Flk1+ Runx1-/- and Tal-1-/- ES cells
In order to identify genes that are activated in differentiating WT ESCs, but are missing in Tal-1-/- and Runx1-/- ESCs, and which might be involved in the generation of definitive hematopoietic progenitors and their specification thereafter, we performed microarray analyses on purified Flk-1+ cells...
ORGANISM(S): Mus musculus 
2013-06-18 | E-GEOD-46970 | biostudies-arrayexpress
TranscriptomicsDifferentially activated CD8 T cells in liver and gut
NaM-CM-/ve, liver- and gut-activated CD8 OT-I T cells show differential migration behaviour. To analyze which genes could be responsible for different migration patterns, naM-CM-/ve, liver-activated and gut-activated CD8 T cells were isolated and compared for their gene expression profile. Gene expr...
ORGANISM(S): Mus musculus 
2014-02-25 | E-GEOD-39449 | biostudies-arrayexpress
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