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While melanoma cells often express a high burden of mutated proteins, the infiltration of reactive T cells rarely results in tumor-eradicating immunity. We discovered that large extracellular vesicles, known as melanosomes, secreted by melanoma cells are decorated with MHC molecules that stimulate C...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2026-04-19 | PXD069094 | Pride
Frameshift insertion/deletions can produce highly immunogenic neoantigens; however, frameshift-derived transcripts are often degraded by the nonsense-mediated mRNA decay (NMD) pathway. Leveraging multiomics and checkpoint in-hibitor (CPI) response data from over 1,000 patients, we demonstrate that r...
ORGANISM(S): Homo sapiens (Human) 
2026-04-07 | PXD073256 | Pride
Aberrant peptides presented by major histocompatibility complex (MHC) molecules are targets for tumor eradication, as these peptides can be recognized as foreign by T cells. Protein synthesis in malignant cells is dysregulated, resulting in the production of non-canonical aberrant peptides. We hypot...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2025-03-25 | PXD053256 | Pride
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