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ProteomicsComprehensive respiratory phenomics across multiple models of mitochondrial protein hyperacylation reveals a paradoxically marginal impact on bioenergetics
Acyl CoA metabolites derived from catabolism of carbon fuels can react with lysine residues of mitochondrial proteins, giving rise to a large family of post-translation modifications (PTMs). Mass spectrometry-based detection of thousands of acyl-PTMs scattered throughout the proteome has established...
ORGANISM(S): Mus Musculus (mouse) 
2019-02-07 | PXD011375 | JPOST Repository
TranscriptomicsTranscription profiling of rat arteries from animals with salt induced hypertensive disease results in over expression of matricellular genes in cerebral arteries
The Dahl salt-sensitive (S) rat model develops chronic hypertensive disease when fed a high salt diet that ultimately results in renal and heart failure, as well as prevalent cerebrovascular pathologies. Phenotypic changes in the cerebral vasculature are preceded by changes in gene expression, and ...
ORGANISM(S): Rattus norvegicus 
2008-06-13 | E-GEOD-5488 | biostudies-arrayexpress
ProteomicsDisruption of acetyl group balance in cardiomyocytes augments the mitochondrial acetylproteome without affecting respiratory function or heart susceptibility to pressure overload
Circumstantial evidence links the development of heart failure to perturbations in oxidative metabolism and corresponding shifts in post-translational modifications (PTMs) of mitochondrial proteins, including lysine acetylation (Kac). Nonetheless, direct evidence that acetyl-PTMs compromise mitochon...
ORGANISM(S): Mus musculus (Mouse) 
2020-10-02 | PXD013935 | Pride
Lc-msms Mitochondria Mouse Heart Acetylation 
UnknownFirst-in-Human Experience With a Novel Multimodality DeepOCT-NIRS Intracoronary Imaging System.
Not available
S-EPMC11308831 | biostudies-literature
UnknownTherapeutic Hypothermia after In-Hospital Cardiac Arrest in Children.
Not available
S-EPMC5310766 | biostudies-literature
UnknownDuration of androgen deprivation therapy with postoperative radiotherapy for prostate cancer: a comparison of long-course versus short-course androgen deprivation therapy in the RADICALS-HD randomised trial.
Not available
S-EPMC7616389 | biostudies-literature
UnknownAdding 6 months of androgen deprivation therapy to postoperative radiotherapy for prostate cancer: a comparison of short-course versus no androgen deprivation therapy in the RADICALS-HD randomised controlled trial.
Not available
S-EPMC7616360 | biostudies-literature
UnknownMetformin for patients with metastatic prostate cancer starting androgen deprivation therapy: a randomised phase 3 trial of the STAMPEDE platform protocol.
Not available
S-EPMC12303861 | biostudies-literature
UnknownPlasma AR Alterations and Timing of Intensified Hormone Treatment for Prostate Cancer: the STAMPEDE Phase 3 Randomized Clinical Trial.
Not available
S-EPMC11869088 | biostudies-literature
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