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UnknownLargazole Arrests Cell Cycle at G1 Phase and Triggers Proteasomal Degradation of E2F1 in Lung Cancer Cells.
Not available
S-EPMC4027503 | biostudies-literature
ProteomicsIdentification of METTL5 interaction partners
METTL5 is an RNA methyltransferase whose stability was noted to be poor when expressed in both mammalian and bacterial expression systems. To determine if METTL5 has an endogenous stabilizing binding partner, FLAG-tagged METTL5 was expressed in Freestyle 293 cells and pulled down with anti-FLAG-M2 a...
ORGANISM(S): Homo sapiens (Human) 
2022-01-27 | PXD029574 | Pride
Mettl5 
ProteomicsThe METTL5-TRMT112 N6-methyladenosine methyltransferase complex regulates metabolism and development via translation (Identification of m1A mRNA methyltransferase in nucleus by TMT11-LC-MS/MS)
m1A has long been known to be important in tRNA and rRNA, but we recently mapped many m1A sites in mRNA as well. m1A is found on the 5’ ends of genes, usually around the first splice site, but we have yet to understand how it effects transcript fate. Identifying the methyltransferase would be a ma...
ORGANISM(S): Homo sapiens (Human) 
2021-11-30 | PXD028832 | Pride
Mettl5 Mass spectrometry Proteomics M1a mrna methyltransferase Trmt112 
UnknownThe METTL5-TRMT112 N6-methyladenosine methyltransferase complex regulates mRNA translation via 18S rRNA methylation.
Not available
S-EPMC8857481 | biostudies-literature
ProteomicsStellettin B renders glioblastoma vulnerable to poly (ADP-ribose) polymerase inhibitors via suppressing homology-directed repair
Glioblastoma (GBM) is the most malignant tumor of the central nervous system. Current first-line post-surgery regimens for GBM including radiotherapy and temozolomide (TMZ) chemotherapy show very limited efficacy, with a median overall survival of only 15 months. Therefore, the development of therap...
ORGANISM(S): Homo Sapiens 
2022-10-11 | PXD037301 |
UnknownThree vs 12-month DAPT after implantation of biodegradable-polymer sirolimus-eluting coronary stent: a randomised clinical trial.
Not available
S-EPMC12729390 | biostudies-literature
UnknownSymptom Burden, Health Status, and Productivity in Patients with Uncontrolled and Controlled Severe Asthma in NOVELTY.
Not available
S-EPMC10274410 | biostudies-literature
UnknownFrom asymmetrical to balanced genomic diversification during rediploidization: Subgenomic evolution in allotetraploid fish.
Not available
S-EPMC7385415 | biostudies-literature
UnknownCharacterization of the extrinsic and intrinsic signatures and therapeutic vulnerability of small cell lung cancers.
Not available
S-EPMC12420805 | biostudies-literature
UnknownTransarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma (CHANCE001).
Not available
S-EPMC9905571 | biostudies-literature
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