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TranscriptomicsThe transcriptome of TRPV1-positive sensory neurons revealed by subgroup-elimination transcriptomics
We developed an approach to rapidly eliminate the subgroup of sensory neurons expressing the heat-gated cation channel TRPV1 from dissociated rat sensory ganglia using agonist treatment followed by density centrifugation. To identify transcripts predomintly expressed in TRPV1-positive neurons, we co...
ORGANISM(S): Rattus norvegicus 
2015-05-12 | E-GEOD-59727 | biostudies-arrayexpress
ProteomicsShort cationic antimicrobial peptide RWRWRW-NH2 inhibits cell wall biosynthesis and bacterial respiration by delocalizing essential membrane proteins
Antimicrobial peptides are potent antibacterial agents. The subclass of short cationic RW-rich peptides is known to target the bacterial membrane. We employed the synthetic hexapeptide RWRWRW-NH2 to characterize in-depth the impact of short cationic RW-rich peptides on bacterial physiology and the b...
ORGANISM(S): Bacillus subtilis subsp. subtilis str. 168 
2014-03-06 | PXD000181 | Pride
Short cationic antimicrobial peptide Bacillus subtilis Antibiotics 
TranscriptomicsTranscription profiling of mouse retinal gene expression after hypoxic preconditioning identifies candidate genes for neuroprotection
Neuroprotective therapies for retinal degeneration may be used to rescue retinal cells and preserve vision. Hypoxic preconditioning stabilizes the transcription factor HIF-1α in the retina and strongly protects photoreceptors in an animal model of light-induced retinal degeneration. Our data sugges...
ORGANISM(S): Mus musculus 
2009-01-17 | E-GEOD-14366 | biostudies-arrayexpress
MetabolomicsNontargeted and targeted metabolomics measurements of abiotic stress responses in three-week-old Arabidopsis thaliana plants' rosette leaf tissue
Nontargeted and targeted metabolomics measurements of abiotic stress responses in three-week-old Arabidopsis thaliana plants' rosette leaf tissue for Col-0 wild type plants and double/triple knockout mutants of aquaporins (pip2;1 pip2;2 and pip2;1 pip2;2 pip2;4) treated with drought, heat at differe...
2017-07-17 | MTBLS355 | MetaboLights
TranscriptomicsTranscription profiling of human TLR2/1 stimulated human monocytes with the Mycobacterium tuberculosis derived 19kDa lipopeptide reveals Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response
In innate immune responses, activation of Toll-like receptors (TLRs) triggers direct antimicrobial activity against intracellular bacteria, which in murine, but not human, monocytes and macrophages is mediated principally by nitric oxide. We report here that TLR activation of human macrophages up-re...
ORGANISM(S): Homo sapiens 
2008-06-17 | E-GEOD-8921 | biostudies-arrayexpress
TranscriptomicsThe transcriptome of TRPV1-positive sensory neurons revealed by subgroup-elimination transcriptomics
We developed an approach to rapidly eliminate the subgroup of sensory neurons expressing the heat-gated cation channel TRPV1 from dissociated rat sensory ganglia using agonist treatment followed by density centrifugation. To identify transcripts predominantly expressed in TRPV1-positive neurons, we ...
ORGANISM(S): Rattus norvegicus 
2015-12-30 | E-MTAB-2789 | biostudies-arrayexpress
UnknownCholesterol transfer via endoplasmic reticulum contacts mediates lysosome damage repair
Not available
S-SCDT-10_15252-EMBJ_2022112677 | biostudies-other
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