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ProteomicsCRISPR-Cas9 genetic screen leads to the discovery of L-Moses, a KAT2B inhibitor that attenuates Tunicamycin-mediated neurodegeneration
Accumulation of aggregated and misfolded proteins, leading to endoplasmic reticulum stress and activation of the unfolded protein response, is a hallmark of several neurodegenerative disorders, including Alzheimer’s and Parkinson’s disease. Genetic screens are powerful tools that are proving invalua...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD038395 | Pride
Cortical neurons Kat2b L-moses Endoplasmic reticulum (er) stress Acetylome 
UnknownDoes Moses technology improve the efficiency and outcomes of standard holmium laser lithotripsy? A systematic review and meta-analysis.
Not available
S-EPMC9903166 | biostudies-literature
UnknownMonths and Severity Score (MOSES) in a Phase III trial (PARCER): A new comprehensive method for reporting adverse events in oncology clinical trials.
Not available
S-EPMC9035686 | biostudies-literature
MetabolomicsOn-line untargeted metabolomics monitoring of an Escherichia coli succinate fermentation process
The real-time monitoring of metabolites (RTMet) is instrumental for the industrial production of biobased fermentation products. This study shows the first application of untargeted on-line metabolomics for the monitoring of undiluted fermentation broth samples taken automatically from a 5 L bioreac...
2023-04-26 | MTBLS5197 | MetaboLights
UnknownInhibition of mitochondrial metabolism by (-)-jerantinine A: synthesis and biological studies in triple-negative breast cancer cells.
Not available
S-EPMC10131581 | biostudies-literature
UnknownMolecular detection of sub-microscopic infections and Plasmodium falciparum histidine-rich protein-2 and 3 gene deletions in pre-elimination settings of South Africa.
Not available
S-EPMC11239831 | biostudies-literature
MetabolomicsLongitudinal multi-omics reveals subset-specific mechanisms underlying irritable bowel syndrome

The gut microbiome has been implicated in multiple human chronic gastrointestinal (GI) disorders. Determining its mechanistic role in disease has been difficult due to apparent disconnects between animal and human studies and lack of an integrated multi-omics view of disease-specific physiologica...

2020-09-08 | MTBLS1396 | MetaboLights
UnknownSouthwest Oncology Group S0802: a randomized, phase II trial of weekly topotecan with and without ziv-aflibercept in patients with platinum-treated small-cell lung cancer.
Not available
S-EPMC4121504 | biostudies-literature
TranscriptomicsExpression data from human liver cell line induced by PCB153
Exposure to Polychlorobiphenyls (PCBs) is known to cause serious health effects in human but the gene expression profiles leading to development of differnet diseases is not fully understood. The knowledge of global gene expression will help us to devlop early diagnostic biomarkers for PCB induced h...
ORGANISM(S): Homo sapiens 
2010-07-21 | E-GEOD-6494 | biostudies-arrayexpress
TranscriptomicsExpression data from human liver cell line induced by PCB77
Exposure to Polychlorobiphenyls (PCBs) is known to cause serious health effects in human but the gene expression profiles leading to development of different diseases is not fully understood. The knowledge of global gene expression will help us to develop early diagnostic biomarkers for PCB induced ...
ORGANISM(S): Homo sapiens 
2010-07-22 | E-GEOD-6869 | biostudies-arrayexpress
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