Sort   by:  
 Page size 
MetabolomicsSubcellular antibiotic visualization reveals a dynamic drug reservoir in infected macrophages
Tuberculosis, caused by the intracellular pathogen Mycobacterium tuberculosis, remains the world's deadliest infectious disease. Sterilizing chemotherapy requires at least 6 months of multidrug therapy. Difficulty visualizing the subcellular localization of antibiotics in infected host cells means t...
2020-12-07 | MTBLS959 | MetaboLights
ProteomicsMetaproteomic analysis of nine coral species with and without Stony Coral Tissue Loss Disease (SCTLD)
Florida’s coral reefs are currently experiencing a multi-year disease-related mortality event, that has resulted in massive die-offs in multiple coral species. Approximately 21 species of coral, including both Endangered Species Act-listed and the primary reef-building species, have displayed tissue...
ORGANISM(S): Colpophyllia natans Orbicella annularis Diploria labyrinthiformis Montastraea cavernosa Dichocoenia stokesii Orbicella faveolata Pseudodiploria strigosa Meandrina meandrites Pseudodiploria clivosa 
2021-05-21 | PXD026192 | Pride
Sctld Metaproteomics Corals 
UnknownEpigenetic targeting of neuropilin-1 prevents bypass signaling in drug-resistant breast cancer.
Not available
S-EPMC7808937 | biostudies-literature
UnknownChemical proteomics tracks virus entry and uncovers NCAM1 as Zika virus receptor.
Not available
S-EPMC7403387 | biostudies-literature
TranscriptomicsTranscription profiling of yeast grown in gastric or duodenal medium to identify promoters that could be used to down-regulate genes used in the release of therapeutic proteins
The use of yeast as a delivery system is an attractive option for the oral administration of therapeutic agents. We recently developed mutants of Saccharomyces cerevisiae capable of lysis upon conditional down-regulation of the expression of the cell wall genes PKC1 and SRB1. The lysis mechanism of ...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-01 | E-MEXP-2127 | biostudies-arrayexpress
UnknownA four-group urine risk classifier for predicting outcomes in patients with prostate cancer.
Not available
S-EPMC6851983 | biostudies-literature
ProteomicsProteogenomic analysis unveils the expression of cancer associated and specific antigen-derived HLA Class ǀ immunopeptides in melanoma and EGFR mutant lung adenocarcinoma
Immunotherapy has shown great therapeutic potential for cancers with high tumor mutational burden (TMB), but much less promise for cancers with low TMB. One primary approach for adoptive lymphocyte transfer-based immunotherapy is to target the somatic mutated peptide neoantigens and cancer testis (C...
ORGANISM(S): Homo sapiens (Human) 
2021-12-07 | PXD019774 | Pride
Hla immunopeptidome Immunotherapy Neoantigen Melanoma Lung cancer 
ProteomicsPhosphoproteins in extracellular vehicles as candidate markers for breast cancer
The state of protein phosphorylation can be a key determinant of cellular physiology such as early stage cancer, but the development of phosphoproteins from biofluids for disease diagnosis remains elusive. Here we demonstrate, for the first time, a strategy to isolate and identify phosphoproteins in...
ORGANISM(S): Homo sapiens (Human) 
2017-03-23 | PXD005214 | Pride
Plasma Extracellular vesicles Phosphoproteomics Biomarker 
ProteomicsProteogenomic analysis unveils the HLA Class I presented immunopeptidome in melanoma and EGFR mutant lung adenocarcinoma
Immune checkpoint inhibitor and adoptive lymphocyte transfer-based therapies have shown great therapeutic potential for cancers with high tumor mutation burden (TMB). Here, we employed mass spectrometry (MS)-based proteogenomic large-scale profiling to identify potential immunogenic human leukocyte ...
ORGANISM(S): Homo sapiens (Human) 
2021-08-23 | PXD022949 | Pride
Hla immunopeptidome Immunotherapy Neoantigen Melanoma Lung cancer 
ProteomicsIdentification of Direct Upstream Kinases by Fluorescence Complementation Mass Spectrometry
Kinase-substrate networks are the main components of many signal transduction pathways. Although proteome-wide studies have been successful in elucidating many important biological events including the cataloging of thousands of sites of protein phosphorylation, there is a lack of a universal method...
ORGANISM(S): Homo sapiens (Human) 
2017-11-08 | PXD004739 | Pride
Fcms Kinases Fluorescence complementation Phosphorylation 
Sort   by:  
 Page size