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TranscriptomicsBRAF-mutation associated DNA methylation in novel CRC cell lines
Background: In vitro models are an essential tool towards understanding the molecular characteristics of colorectal cancer (CRC) and the testing of therapies for CRC. To this end we established 21 novel CRC cell lines of which six were derived from liver metastases. Extensive genetic, genomic, trans...
ORGANISM(S): Homo sapiens 
2016-02-29 | E-GEOD-67772 | biostudies-arrayexpress
TranscriptomicsSNP-array profiling of 21 novel primary and metastatic colorectal cancer cell lines [Illumina HumanExome-12 v1.2 BeadChip]
Background: In vitro models are an essential tool towards understanding the molecular characteristics of colorectal cancer (CRC) and the testing of therapies for CRC. To this end we established 21 novel CRC cell lines of which six were derived from liver metastases. Extensive genetic, genomic, trans...
ORGANISM(S): Homo sapiens 
2016-02-29 | E-GEOD-67774 | biostudies-arrayexpress
TranscriptomicsSNP-array profiling of 21 novel primary and metastatic colorectal cancer cell lines [Illumina HumanExome-12 v1.0 BeadChip]
Background: In vitro models are an essential tool towards understanding the molecular characteristics of colorectal cancer (CRC) and the testing of therapies for CRC. To this end we established 21 novel CRC cell lines of which six were derived from liver metastases. Extensive genetic, genomic, trans...
ORGANISM(S): Homo sapiens 
2016-02-29 | E-GEOD-67773 | biostudies-arrayexpress
UnknownConveying facial expressions to blind and visually impaired persons through a wearable vibrotactile device.
Not available
S-EPMC5870993 | biostudies-literature
ProteomicsMetabolic engineering of Streptomyces peucetius for biosynthesis of N,N-dimethylated anthracyclines
Daunorubicin and doxorubicin, two anthracycline polyketides produced by Streptomyces peucetius, are potent anticancer agents that are widely used in chemotherapy, despite severe side effects. Recent advances have highlighted the potential of producing improved derivatives with reduced side effects b...
ORGANISM(S): Streptomyces peucetius subsp. caesius 
2024-01-18 | PXD048604 | Pride
Streptomyces peucetius Lfq Maxquant Qexactive 
ProteomicsReconstruction, refinement and validation of a Streptomyces coelicolor consensus genome scale metabolic model
The rapid rise in antibiotic-resistance of microbial pathogens has brought the attention to new, heterologous approaches to better exploit the vast repertoire of biosynthetic gene clusters in Actinobacteria genomes and the large number of potentially novel bioactive compounds encoded in these. To en...
ORGANISM(S): Streptomyces coelicolor A3(2) 
2020-09-10 | PXD013178 | Pride
Metabolic model Scogem Streptomyces coelicolor 
TranscriptomicsHigh Resolution Copy Number Analysis of Paraffin Embedded Archival Tissue Using SNP BeadArrays
High density SNP microarrays provide insight into the genomic events that occur in diseases like cancer by their capability to measure both LOH and genomic copy numbers. Where currently available methods are restricted to the use of fresh frozen tissue, we now describe the design and validation of c...
ORGANISM(S): Homo sapiens 
2006-09-01 | E-GEOD-5347 | biostudies-arrayexpress
UnknownBioturbation Affects Bioaccumulation: PFAS Uptake from Sediments by a Rooting Macrophyte and a Benthic Invertebrate.
Not available
S-EPMC11580174 | biostudies-literature
TranscriptomicsCombined arrayCGH and SNP-loss of heterozygosity analysis in cervical cancer
BACKGROUND: Cervical carcinoma develops as a result of multiple genetic alterations. Different studies investigated genomic alterations in cervical cancer mainly by means of metaphase comparative genomic hybridization (mCGH) and microsatellite marker analysis for the detection of loss of heterozygos...
ORGANISM(S): Homo sapiens 
2010-06-05 | E-GEOD-8605 | biostudies-arrayexpress
ProteomicsProteomics survey of Streptomyces coelicolor strains with natural gross chromosome change
Streptomyces coelicolor normally produce spores with a relatively high heterogeneity, which will produce genetically heterogeneous sub-populations. These sub-populations often exert massive chromosome amplifications and deletions. Cells with gross chromosomal changes produce an increased diversity o...
ORGANISM(S): Streptomyces coelicolor Bacteria 
2020-05-26 | PXD014413 | Pride
Antibiotics over-production Streptomyces coelicolor Bacteria social behavior Chromosome change Division of labour 
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