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GenomicsCombined RNA-seq and Polr2a ChIP-seq Identifies Gene Targets for Transcriptional Regulation in Vasopressin-Sensitive Collecting Duct Cells
In mammals, the peptide hormone vasopressin controls renal water excretion, largely through its actions in the renal collecting duct to regulate the molecular water channel aquaporin-2 (AQP2). There are two modes of regulation: 1) short-term regulation by membrane trafficking; and 2) long-term regu...
ORGANISM(S): Mus musculus 
2016-07-01 | E-GEOD-79573 | biostudies-arrayexpress
UnknownAssociation of liver biomarker values beyond current thresholds and negative clinical outcomes in primary biliary cholangitis: analysis of a real-world healthcare claims database.
Not available
S-EPMC12679663 | biostudies-literature
GenomicsIL-10 production and metabolic regulation in macrophages are linked by a TLR-driven CREB-mediated mechanism
IL-10 is produced by macrophages in diverse immune settings and is critical in limiting immune-mediated pathology. In helminth infections macrophages are an important source of IL-10, however the molecular mechanism underpinning production of IL-10 by these cells is poorly characterized. Here, bone ...
ORGANISM(S): Mus musculus 
2015-07-08 | E-GEOD-64844 | biostudies-arrayexpress
UnknownSpheroidal carbonaceous particles are a defining stratigraphic marker for the Anthropocene.
Not available
S-EPMC4603698 | biostudies-literature
UnknownScanning the horizon: towards transparent and reproducible neuroimaging research.
Not available
S-EPMC6910649 | biostudies-literature
Genomicsseq-WA30534819_H3K4me3_N2_MXemb
modENCODE_submission_3169 We analyzed H3 lysine 4 trimethylation levels in the C. elegans genome using chromatin immunoprecipitation followed by Illumina sequencing. We used wild type (N2) mixed developmental stage embryos and performed the experiment in two biological replicates. This series consis...
ORGANISM(S): Caenorhabditis elegans 
2010-09-24 | E-GEOD-24318 | biostudies-arrayexpress
Genomicsseq-SDQ3891_LEM2_N2_MXemb
modENCODE_submission_3168 Although C. elegans was the first multicellular organism with a completely sequenced genome, how this genome is arranged within the nucleus is not known. By chromatin immunoprecipitation of the nuclear transmembrane protein LEM-2, we determined the regions of the C. elegans...
ORGANISM(S): Caenorhabditis elegans 
2010-09-21 | E-GEOD-24241 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of endotoxin-stimulated human monocytic cells in presence and absence of host defense peptide LL-37
The objective of the study was to evaluate transcriptional response of endotoxin-stimulated human monocytic cells in presence and absence of host defense peptide LL-37. A functional genomics approach was used to establish a temporal transcriptional profile and identify differentially expressed gene...
ORGANISM(S): Homo sapiens 
2006-08-01 | E-FPMI-4 | biostudies-arrayexpress
TranscriptomicsSOX9 modulates the expression of key transcription factors required for heart valve development
Heart valve formation initiates when endothelial cells of the heart transform into mesenchyme and populate the cardiac cushions. The transcription factor, SOX9, is highly expressed in the cardiac cushion mesenchyme, and is essential for heart valve development. Loss of Sox9 in mouse cardiac cushion ...
ORGANISM(S): Mus musculus 
2015-11-05 | E-GEOD-73225 | biostudies-arrayexpress
UnknownTherapeutic Impact of Cytoreductive Surgery and Irradiation of Posterior Fossa Ependymoma in the Molecular Era: A Retrospective Multicohort Analysis.
Not available
S-EPMC4962737 | biostudies-literature
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