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MetabolomicsLaser-assisted rapid evaporative ionisation mass spectrometry (LA-REIMS) as a metabolomics platform in cervical cancer screening

BACKGROUND: The introduction of high-risk human papillomavirus (hrHPV) testing as part of primary cervical screening is anticipated to improve sensitivity, but also the number of women who will screen positive. Reflex cytology is the preferred triage test in most settings but ha...

2022-02-15 | MTBLS1371 | MetaboLights
MetabolomicsSymptomatology and Serum Nuclear Magnetic Resonance Metabolomics; Do They Predict Endometriosis in Fertile Women Undergoing Laparoscopic Sterilisation? A Prospective Cross-sectional Study
Endometriosis is a common, chronic inflammatory condition, thought to have a higher incidence in symptomatic women, yet, commonly associated symptoms do not always correlate with the presence or severity of disease and diagnosis requires surgery. We prospectively collected data and assessed symptomo...
2023-05-26 | MTBLS2040 | MetaboLights
TranscriptomicsExpression data of Col:LUC Arabidopsis treated with antimycin A (AA) in the presence or absence of a synthetic auxin analogue
Mitochondrial stress stimuli such as AA caused a transient suppression of auxin signaling and conversely, auxin treatment represses a part of the response to AA treatment. Expression data of Col:LUC Arabidopsis treated with antimycin A (AA) in the presence or absence of a synthetic auxin analogue To...
ORGANISM(S): Arabidopsis thaliana 
2014-06-01 | E-GEOD-57140 | biostudies-arrayexpress
TranscriptomicsExpression data of germinating Arabidopsis seeds
In depth temporal profiling of transcript changes at 10 time points during germination in Arabidopsis seed was carried out. The time course utilised, encompassed seed maturation, stratification, germination and post-germination and provided a global investigation into the tightly regulated, phasic c...
ORGANISM(S): Arabidopsis thaliana 
2011-09-08 | E-GEOD-30223 | biostudies-arrayexpress
ProteomicsA revised molecular model of ovarian cancer biomarker CA125 (MUC16) enabled by long-read sequencing
The biomarker CA125, a peptide epitope located in several tandem repeats of the mucin MUC16, is the gold-standard for monitoring regression and recurrence of high-grade serous ovarian cancer in response to therapy. However, the CA125 epitope along with several structural features of the MUC16 molecu...
ORGANISM(S): Homo sapiens (Human) 
2024-05-21 | PXD044117 | Pride
Proteomics Ovarian cancer Ca125 Biomarker Muc16 Nanopore sequencing 
ProteomicsImmunoaffinity-free chromatographic purification of ovarian cancer biomarker CA125 (MUC16) from blood serum
The present work developed a non-affinity-based chromatographic method to enrich MUC16 from serum. The enriched MUC16 sample was further processed using a Midi Top 14 abundant protein depletion column. Peptides identified using bottom-up proteomics yielded 1–8% coverage of MUC16. Additionally, MUC16...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD053289 | Pride
Human Plasma Ovarian Muc16 Ca125 
ProteomicsMRM Analysis of Cap, Ven and plasma
Samples were quantitatively analyzed by a liquid chromatography-multiple reaction monitoring-mass spectrometry method targeting 114 peptides representing 60 HSP proteins and by a data-independent acquisition mass spectrometry discovery method, resulting in up to 3,811 protein identifications. The ...
ORGANISM(S): Homo sapiens (Human) 
2023-10-17 | PXD038678 | Pride
Plasma mrm Capillary blood Venous blood 
TranscriptomicsTempo-Seq targeted RNA sequencing of the HepaRG cell line treated with aflatoxin B1, benzo[a]pyrene, cyclosporin A, rotenone and thrichostatin A over a range of chemical concentrations and exposure time points
The experiment investigates the effects of five well-known chemicals on the transcriptome of the HepaRG cell line, a metabolically competent hepatic cell line. The cells were treated individually with an increasing concentrations of aflatoxin B1, benzo[a]pyrene, cyclosporine A, rotenone or trichost...
ORGANISM(S): Homo sapiens 
2023-08-01 | E-MTAB-13168 | biostudies-arrayexpress
ProteomicsInfluence of generational obesity on the visceral adipose proteome
Obesity is a global health concern affecting over 650 million adults with a major contributor being an increased consumption of a high-fat diet. Maternal obesity often results in an increased risk of offspring developing obesity. In this study, we examined the effect of diet on visceral adipose in ...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-17 | PXD042092 | Pride
Proteomics Suspension trapping Generational obesity Omental tissue Adipose tissue Mouse Diet S-trap 
ProteomicsSimultaneous N-deglycosylation and digestion of human and chicken proteins on S-Traps
N-linked glycosylation is an important post-translational modification that is difficult to identify and quantify in traditional bottom-up proteomics experiments. Enzymatic deglycosylation of proteins by peptide:N-glycosidase F (PNGase F) prior to digestion and subsequent mass spectrometry analysis ...
ORGANISM(S): Homo sapiens (Human) Gallus gallus (Chicken) 
2023-02-09 | PXD037921 | Pride
Human Deglycosylation Chicken S-trap Lc-ms/ms 
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