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TranscriptomicsEpigenomic profiling in visceral white adipose tissue of offspring of mice exposed to late gestational sleep fragmentation
Background: Late gestational sleep fragmentation (LG-SF) is one of the major perturbations associated with sleep apnea and other sleep disorders during pregnancy. Objectives: To investigate the effects of late LG-SF on the epigenome of visceral white adipose tissue (VWAT) in the offspring. Methods: ...
ORGANISM(S): Mus musculus 
2015-04-02 | E-GEOD-63208 | biostudies-arrayexpress
TranscriptomicsMicroarray analyses of laser-captured hippocampus reveal distinct gray and white matter signatures associated with incipient Alzheimer’s disease
Alzheimer's disease (AD) is a devastating neurodegenerative disorder that threatens to reach epidemic proportions as our population ages. Although much research has examined molecular pathways associated with AD, relatively few studies have focused on critical early stages. Our prior microarray stud...
ORGANISM(S): Homo sapiens 
2011-07-31 | E-GEOD-28146 | biostudies-arrayexpress
TranscriptomicsObesity drives depot-specific vascular remodeling in white adipose tissue
Obesity-driven pathological expansion of white adipose tissue (WAT) is a key driver of endothelial dysfunction. Contrary to this paradigm, early vascular alterations associated with over nutrition also exacerbate AT dysfunction. To dissect this complex cause and consequence relationship, here we per...
ORGANISM(S): Mus musculus 
2023-05-26 | E-MTAB-12855 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of laparoscopic donor nephrectomy samples compared to healthy control kidneys
We compared gene expression profiles from six donor kidneys prior to surgical manipulation to six kidneys removed after laparoscopic donor nephrectomy (LDN) and several hours of CO2 pneumoperitoneum. Biopsies were obtained from renal cortex and hybridized to Affymetrix HG-U133A GeneChips. For cont...
ORGANISM(S): Homo sapiens 
2005-09-14 | E-GEOD-3297 | biostudies-arrayexpress
UnknownEffects of atorvastatin on biomarkers of immune activation, inflammation, and lipids in virologically suppressed, human immunodeficiency virus-1-infected individuals with low-density lipoprotein cholesterol <130 mg/dL (AIDS Clinical Trials Group Study A5275).
Not available
S-EPMC5407297 | biostudies-literature
TranscriptomicsThe roles of ppar-delta and ppar-gamma in regulating the metabolic switch between oxidation and storage of fats in white adipose tissue
Obesity is a major risk factor for the development of insulin resistance and type II diabetes. The nuclear receptors PPAR delta and PPAR gamma play a central role in regulating metabolism in adipose tissue, as well as being targets for the treatment of insulin resistance. The metabolic effects of PP...
ORGANISM(S): Mus musculus 
2011-07-13 | E-GEOD-26207 | biostudies-arrayexpress
TranscriptomicsRabbit heart gene expression in Left ventricle (LV) following banding of the descending thoracic aorta (AOB-LV) vs Sham-control LV and in Right ventricle (RV) following banding the pulmonary artery (PAB-RV) vs. Sham-control RV
Background: Right ventricular (RV) and left ventricular (LV) myocardium differ in their response to pressure-overload hypertrophy (POH). In this report we use microarray and proteomic analyses to identify pathways modulated by LV-, and RV-POH in the immature heart. Methods: Newborn New Zealand White...
ORGANISM(S): Oryctolagus cuniculus 
2011-06-24 | E-GEOD-30194 | biostudies-arrayexpress
TranscriptomicsGenome-wide polysome analysis in poly(I:C)-treated WT and Oasl1-/- BMDM.
OASL1 is a novel translation inhibitor for the type I IFN master transcription factor IRF7. To examine whether OASL1 specifically inhibit IRF7 translation, we used a genome-wide gene expression microarray to screen for the polysome-associated mRNAs more enriched in the OASL1 KO BMDMs. The microarray...
ORGANISM(S): Mus musculus 
2013-02-17 | E-GEOD-41787 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression in motor pools with differential vulnerability in ALS
ALS is a uniformly fatal neurodegenerative disease in which motor neurons in the spinal cord and brain stem are selectively lost. Individual motor - groups of motor neurons innervating single muscles - show widely varying degrees of disease resistance: in the final stages of ALS, nearly all voluntar...
ORGANISM(S): Mus musculus 
2013-11-15 | E-GEOD-52118 | biostudies-arrayexpress
ProteomicsKlein / Husselmann chia under salt and caffeic acid stress
Husselmann 2017: Following gel and TOF/TOF investigation of chia salinity stress by Achmat Williams [http://hdl.handle.net/11394/5650], Husselmann and Klein designed an LC-MS/MS experiment for five replicates in each of five cohorts: caffeic acid stress, salt stress, both stresses, and controls for ...
ORGANISM(S): Salvia Hispanica (ncbitaxon:49212) 
2021-02-12 | MSV000086861 | MassIVE
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