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ProteomicsPatch-Clamp Proteomics of Single Neurons in Tissue Using Electrophysiology and Subcellular Capillary Electrophoresis Mass Spectrometry
In this project, we enabled mass spectrometry based proteomics characterization of single neurons in sections of the mouse brain. We accessed cells in a whole-cell patch clamp configuration and aspirated a portion of the neuronal soma into the patch clamp probe. The collected aspirate was expelled ...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-18 | PXD028040 | Pride
Electrophysiology Mass spectrometry Nervous system Bottom-up proteomics Capillary electrophoresis Whole-cell patch-clamp Mouse 
TranscriptomicsMorphological, electrophysiological and transcriptomic profiling of single neurons using Patch-seq
The mammalian neocortex is a layered sheet of neural tissue that mediates complex cognitive processes including perception and cognition. Despite its importance, we still lack detailed knowledge of the cellular components of the neocortex. Integrating morphological, electrophysiological and molecula...
ORGANISM(S): Mus musculus 
2016-01-25 | E-MTAB-4092 | biostudies-arrayexpress
UnknownAutomated whole-cell patch-clamp electrophysiology of neurons in vivo.
Not available
S-EPMC3427788 | biostudies-literature
UnknownRobotic Automation of In Vivo Two-Photon Targeted Whole-Cell Patch-Clamp Electrophysiology.
Not available
S-EPMC5584670 | biostudies-literature
ProteomicsProteome-Driven Phenotyping of Identified Single Neurons in Intact Brain Tissue by Capillary Electrophoresis–timsTOF Mass Spectrometry Patch Proteomics
This project developed an ultrahigh-sensitivity proteomics platform in the discovery setting to profile the proteome of cell bodies (somas) between different types of neurons in the mouse central nervous system. The soma contents of mitral cells, serotonergic neurons, dopaminergic neurons, and parva...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-28 | PXD077382 | Pride
Serotonin Dopamine Parvalbumin neuron Whole-cell patch clamp Mass spectrometry Fluorescence label Nervous system Bottom-up proteomics Olfactory bulb Mitral cell Capillary electrophoresis Mouse 
TranscriptomicsSingle-cell RNA sequencing of aspirates from cortical neurons after patch clamp recording
We obtained full transcriptome data from single cortical neurons after whole-cell patch-clamp recording (termed “Patch-seq”). By applying “Patch-seq” to cortical neurons, we reveal a close link between biophysical membrane properties and genes coding for neurotransmitter receptors and channels, incl...
ORGANISM(S): Mus musculus 
2015-12-21 | GSE70844 | GEO
UnknownComputer modeling of whole-cell voltage-clamp analyses to delineate guidelines for good practice of manual and automated patch-clamp.
Not available
S-EPMC7870888 | biostudies-literature
UnknownDirect whole-cell patch-clamp recordings from small boutons in rodent primary neocortical neuron cultures.
Not available
S-EPMC10026040 | biostudies-literature
UnknownDendritic patch-clamp recording.
Not available
S-EPMC7616975 | biostudies-literature
UnknownMethod for Rapid Enzymatic Cleaning for Reuse of Patch Clamp Pipettes: Increasing Throughput by Eliminating Manual Pipette Replacement between Patch Clamp Attempts.
Not available
S-EPMC8329470 | biostudies-literature
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