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MetabolomicsGut-Muscle Axis Regulates Meat Quality in Lambs: Rumen Microbiota-Differentiated L-Arginine and Serotonin Signaling Mediates Muscle Lipid Remodeling

This study investigated age-associated changes in the gut-muscle axis and their potential contribution to meat quality in Tan sheep (Ovis aries). Twelve Tan sheep were divided into two age groups, including six 3-month-old animals (T3) and six 6-month-old animals (T6). Untargeted LC-MS metabolomi...

2026-09-03 | MTBLS15419 | MetaboLights
TranscriptomicsExpression Profile of Embryonic Stem Cell Derived Serotonin Neurons
The rhesus embryonic stem cell line 366.4 differentiates into serotonin neurons. RNA was extracted from ESC colonies, embryoid body (Ebs), Neurospheres in selection (N1), Proliferating serotonin neurons (N2) and differentiating serotonin neurons (N3). RNA was labeled with Enzo biotin labelling kit a...
ORGANISM(S): Macaca mulatta 
2010-04-08 | E-GEOD-16168 | biostudies-arrayexpress
TranscriptomicsDistinct Cellular Origins for Serotonin-Expressing and Enterochromaffin-like Cells in the Gastric Corpus
The alimentary tract contains a diffuse endocrine system comprising enteroendocrine cells that secrete peptides or biogenic amines to regulate digestion, insulin secretion, food intake, and energy homeostasis. Lineage analysis in the stomach revealed that a significant fraction of endocrine cells in...
ORGANISM(S): Mus musculus 
2013-12-12 | E-GEOD-53214 | biostudies-arrayexpress
TranscriptomicsInhibition of Peripheral Serotonin Activates Hepatic AMPK and Reduces Monocyte-Derived Liver Macrophages, Ameliorating Obesity-Associated Fibrosis
Monocyte-derived liver macrophages are critical in the pathogenesis of metabolic dysfunction-associated steatohepatitis (MASH) and liver fibrosis, but their recruitment mechanisms remain unclear. Serotonin (5-hydroxytryptamine, 5HT) is a conserved monoamine synthesized by tryptophan hydroxylase (Tph...
ORGANISM(S): Mus musculus 
2025-10-30 | E-MTAB-15760 | biostudies-arrayexpress
ProteomicsProteomics of serotonergic autoregulation
Serotonin regulates its own production, degradation and release in the Raphe nuclei of the brain mainly by modifying the level and activity of autoreceptors on serotonin-producing neurons, such as 5-HT1A and 5-HT1B. This autoregulation is probably the reason for the delayed response of patients with...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD055579 | Pride
Serotonin Serotonin transporter Brain Tryptophan hydroxylase Autoregulation Mouse 
TranscriptomicsImpact of Elevated Plasma 5-HT on Global Gene Expression of Murine Megakaryocytes
The goal of this project was to understand the functional consequences of plasma biogenic amine serotonin (5-HT) elevation in megakaryocytes by measuring gene expression Total RNA was extracted from the megakaryocytes of mice treated with either 5-HT or saline and global gene expression was measured...
ORGANISM(S): Mus musculus 
2014-04-04 | E-GEOD-37273 | biostudies-arrayexpress
TranscriptomicsRNA-seq of pancreatic islets from pregnant mice
During pregnancy, the energy requirements of the fetus impose changes in maternal metabolism. Increasing insulin resistance in the mother maintains nutrient flow to the growing fetus, while prolactin and placental lactogen counterbalance this resistance and prevent maternal hyperglycemia by driving ...
ORGANISM(S): Mus musculus 
2010-07-01 | E-GEOD-21860 | biostudies-arrayexpress
TranscriptomicsPhotoperiod regulates genes encoding melanocortin 3 and serotonin receptors, and secretogranins expressed in the dmpARC of the Siberian hamster
The mechanism(s) involved in the regulation of the seasonal-appropriate body weight of the Siberian hamster is currently unknown. We have identified photoperiodically regulated genes including VGF in a sub-region of the arcuate nucleus termed the dorsomedial posterior arcuate (dmpARC). Gene expressi...
ORGANISM(S): Phodopus sungorus 
2010-05-15 | E-GEOD-10278 | biostudies-arrayexpress
ProteomicsPseudomonas fluorescens - response to serotonin (proteomics)
Pseudomonas fluorescens MFY63 (isolated from human) was incubated with and without 100 micromolar serotonin. The cell pellets were collected after 12 or 24 hours of incubation and the proteome was extracted.
ORGANISM(S): Pseudomonas Fluorescens (ncbitaxon:294) 
2025-04-23 | MSV000097696 | MassIVE
ProteomicsPseudomonas fluorescens - metabolism of and response to serotonin
Pseudomonas fluorescens MFY63 (isolated from human) was incubated with 10 or 100 micromolar serotonin. The culture supernatants were collected after 12 or 24 hours of incubation and extracted using ethyl acetate. Negative (NEG) and positive (POS) polarity data were obtained on a HR-LC-MS/MS setup.
ORGANISM(S): Pseudomonas Fluorescens (ncbitaxon:294) 
2025-02-26 | MSV000097220 | MassIVE
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