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ProteomicsWhole-genome transformation for industrial yeast strain development
tRNAs are encoded by a large gene family, usually with several isogenic tRNAs interacting with the same codon. Mutations in the anticodon region of other tRNAs can overcome specific tRNA deficiencies. Phylogenetic analysis suggests that such mutations have occurred in evolution, but the driving forc...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-09-10 | PXD024655 | Pride
Anticodon Thermotolerance Trna Yeast Whole-genome transformation 
TranscriptomicsWhole genome profile of SWNCT and MWCNT vs. asbestos subchronic exposures to human small airway epithelial cells
Recent in vivo studies reported that inhaled carbon nanotube distribute in the alveolar region resulting in an acute inflammation, progressive fibrotic response and particle accumulation at the bronchoalveolar junction with low clearance. With similar biopersistence and shape as asbestos, a known l...
ORGANISM(S): Homo sapiens 
2013-07-22 | E-GEOD-41178 | biostudies-arrayexpress
GenomicsWhole-genome sequencing of thermotolerant Saccharomyces cerevisiae isolates generated by whole-genome transformation
Whole-genome sequencing of thermotolerant Saccharomyces cerevisiae isolates generated by whole-genome transformation
PRJEB121322 | ENA
TranscriptomicsLipoic acid prevents Cr6+ induced cell transformation and the associated genomic dysregulation.
Investigation of the transcription profile of cells transformed by Cr6+ in vivo was undertaken. The objective was to elucidate genomic changes underlying the mechanism of action of the carcinogenic dose of Cr6+and their prevention using metabolic antioxidant Lipoic acid (LA). Cr6+ was administered i...
ORGANISM(S): Mus musculus 
2013-05-01 | E-GEOD-41419 | biostudies-arrayexpress
TranscriptomicsGenome-wide copy number analyses reveal genomic abnormalities involved in transformation of follicular lymphoma
We studied 277 lymphoma samples (198 FL and 79 transformed FL [tFL]) using a single-nucleotide polymorphism array to identify the secondary chromosomal abnormalities that drive the development of FL and its transformation to diffuse large B-cell lymphoma. Affymetrix 250K NspI SNP arrays were perform...
ORGANISM(S): Homo sapiens 
2015-03-30 | E-GEOD-67385 | biostudies-arrayexpress
GenomicsmethylSig: a whole genome DNA methylation analysis pipeline
DNA methylation plays critical roles in gene regulation and cellular specification without altering DNA sequences. The wide application of reduced representation bisulfite sequencing (RRBS) and whole genome bisulfite sequencing (bis-seq) opens the door to study DNA methylation at single CpG site re...
ORGANISM(S): Homo sapiens 
2014-08-22 | E-GEOD-55569 | biostudies-arrayexpress
TranscriptomicsDual regulation of Fbw7 function and oncogenic transformation by Usp28
Fbw7, the substrate recognition subunit of SCF(Fbw7) ubiquitin ligase, mediates turnover of multiple proto-oncoproteins and promotes its own degradation. Fbw7-mediated substrate degradation is antagonized by the Usp28 deubiquitinase. We now show, using knockout mice, that Usp28 preferentially deubiq...
ORGANISM(S): Mus musculus 
2015-05-01 | E-GEOD-59354 | biostudies-arrayexpress
TranscriptomicsWhole genome ChIP/chip tiling of human ES cells for H3K4me3 and H3K27me3
Chromatin immunoprecipitation was performed using monoclonal antibodiesd. DNA was amplified, fluorescently labeled and hybridized to a series of 38 arrays containing a total of 14.6 million 50-mer oligonucleotides Keywords: ChIP-chip hES whole genome Chromatin immunoprecipitated DNA from H3K4me
ORGANISM(S): Homo sapiens 
2007-09-14 | E-GEOD-8463 | biostudies-arrayexpress
GenomicsEvolutionary Genome Analysis of Transformation into Small Cell Carcinomas from Lung Adenocarcinomas
Anecdotal case have been reported lung adenocarcinoma could occasionally transform into small cell carcinoma. Most of the reported cases were EGFR-mutant lung adenocarcinomas that transform into small cell carcinoma during EGFR tyrosine kinase inhibitor treatment. However, some cases also indicate l...
EGAS00001001757 | EGA
UnknownWhole-Genome Transformation Promotes tRNA Anticodon Suppressor Mutations under Stress.
Not available
S-EPMC8092322 | biostudies-literature
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