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ProteomicsThe GCN-2/eIF-2α/ATF-4 signaling pathway regulates C. elegans defense against pathogen infection
In response to external or endogenous insults, eukaryotic cells can activate a common adaptive pathway called the integrated stress response (ISR). The ISR reduces global protein translation but upregulates the expression of stress response proteins to either restore cellular homeostasis or, in case...
ORGANISM(S): Caenorhabditis elegans 
2025-10-01 | PXD058186 | Pride
Atf4 Collagens Gcn2 Mitochondrial electron transport C. elegans Bacterial infection Eif2α Ribosomal proteins Integrated stress response 
ProteomicsNeuronal GPCR NMUR-1 regulates energy homeostasis in response to pathogen infection in Caenorhabditis elegans
The neuronal G protein-coupled receptor NMUR-1, a homolog to the mammalian neuromedin U receptor, has been implicated in the specificity of Caenorhabditis elegans innate immune response against pathogen infections. NMUR-1 controls C. elegans transcription activity by regulating transcription factors...
ORGANISM(S): Caenorhabditis elegans 
2025-10-02 | PXD045826 | Pride
Caenorhabditis elegans F1fo atp synthase Immunity Pathogen infection G-protein coupled receptors Nmur-1 
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