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TranscriptomicsElucidating the molecular pathways active in chemoresistant head and neck cancer stem cells and their role in resistance
Recurrent or metastatic head and neck squamous cell carcinoma (HNSCC) has a poor prognosis with less than 1-year median survival. Platinum-based chemotherapy (cisplatin or carboplatin) remains the first-line treatment for HNSCC. The cancer stem cell (CSC) hypothesis postulates that tumors are mainta...
ORGANISM(S): Homo sapiens 
2016-06-01 | E-GEOD-72384 | biostudies-arrayexpress
ProteomicsB7-H4 post-translational modifications
B7-H4 functions as an immune checkpoint in the tumor microenvironment (TME). However, the post-translational modification (PTM) of B7-H4 and its translational potential in cancer remains incompletely understood. We found that ZDHHC3, a zinc finger DHHC-type palmitoyltransferase, palmitoylates B7-H4 ...
ORGANISM(S): Homo sapiens (Human) 
2025-02-14 | PXD054393 | Pride
Lysosome Palmitoylation Breast cancers Abemaciclib B7-h4 
TranscriptomicsMyeloid derived suppressor cells enhance stemness of cancer cells by inducing miRNA101 and suppressing the corepressor CtBP2
The work identifies an immune associated cellular, molecular and clinical network involving MDSCs-microRNA101-CtBP2-stem cell core genes, which extrinsically controls cancer stemness and impacts patient outcome. Primary ovarian cancer cells (5 x105) were co-cultured with freshly sorted ovarian cance...
ORGANISM(S): Homo sapiens 
2013-08-23 | E-GEOD-50082 | biostudies-arrayexpress
TranscriptomicsSingle cell RNA-seq of an native and engineered metastatic niche in a metastatic breast cancer murine model
Metastatic lesions are typically not found until patients self-report symptoms or they become radiologically evident. We have developed an engineered metastatic niche (scaffold) that recruits aggressive tumor cells prior to their colonization in other organs. The engineered niche can be monitored fo...
ORGANISM(S): Mus musculus 
2022-08-02 | E-MTAB-8503 | biostudies-arrayexpress
UnknownFlower lose, a cell fitness marker, predicts COVID-19 prognosis.
Not available
S-EPMC8573598 | biostudies-literature
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