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Environment-mediated drug resistance (EMDR) limits the efficacy of cancer therapies by providing anti-apoptotic signals from a non-malignant microenvironment to tumour cells. We show that EMDR is regulated by protein kinase C in stromal cells is required for EMDR. We used plasma membrane profiling t...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-08 | PXD011062 | Pride
Assessing the impact of genomic alterations on protein networks is fundamental in identifying the mechanisms that shape cancer heterogeneity. We have used isobaric labelling to characterize the proteomic landscapes of 50 colorectal cancer cell lines and to decipher the functional consequences of som...
ORGANISM(S): Homo sapiens (Human) 
2017-08-09 | PXD005235 | Pride
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