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GenomicsInhibitors of the histone lysine demethylase KDM1A are broadly efficacious in AML by evicting the enzyme from chromatin [ChIP-Seq]
Examine the distribution of KDM1A and the histone H3K4me2 mark on chromatin following treatment with two distinct classes of KDM1A inhibitors - an irreversible inhibitor (RN-1) and a reversible inhibitor (GSK690) 15 samples total from two treated cell lines - 9 from Kasumi-1 and 6 from SKNO-1. Cont...
ORGANISM(S): Homo sapiens 
2016-02-10 | E-GEOD-71739 | biostudies-arrayexpress
GenomicsGenome-wide chromatin maps of T-cell acute lymphoblastic leukemia (T-ALL) [ChIP-seq]
Here we modeled T-ALL resistance to Notch inhibition, identifying M-bM-^@M-^XpersisterM-bM-^@M-^Y cells that readily expand in the presence of gamma secretase inhibitor (GSI) and the absence of Notch signaling. Rare persister cells are already present in naM-CM-/ve T-ALL populations, and the reversi...
ORGANISM(S): Homo sapiens 
2014-03-01 | E-GEOD-54379 | biostudies-arrayexpress
UnknownHistone-lysine N-methyltransferase SETDB1 is required for development of the bovine blastocyst.
Not available
S-EPMC4591208 | biostudies-literature
TranscriptomicsMethylation profiling of Malignant Rhabdoid Tumours
An observational experiment to methylation profile 79 SMARCB1 negative primary tumours from patients diagnosed with Malignant Rhabdoid Tumours.
ORGANISM(S): Homo sapiens 
2020-07-15 | E-MTAB-6708 | biostudies-arrayexpress
TranscriptomicsmRNA cap methylation in pluripotency and differentiation
The mRNA cap recruits factors essential for transcript processing and translation initiation. We report that regulated mRNA cap methylation is a feature of embryonic stem cell (ESC) differentiation. Expression of the mRNA cap methyltransferase activating subunit, RAM, is elevated in ESCs resulting i...
ORGANISM(S): Mus musculus 
2016-06-14 | E-GEOD-81849 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of benign epithelial and prostate cancer cell lines derived from the same patient
Copy number alterations in a matched pair of benign epithelial and prostate cancer cell lines derived from the same patient were assessed using array-based comparative genomic hybridisation (aCGH). the cancer cell line showed a gain of chromosome 7, deletion of chromosome 8, gains and losses in chro...
ORGANISM(S): Homo sapiens 
2006-08-04 | E-MEXP-803 | biostudies-arrayexpress
UnknownmRNA Cap Methylation in Pluripotency and Differentiation.
Not available
S-EPMC4977272 | biostudies-literature
UnknownTASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control.
Not available
S-EPMC7532188 | biostudies-literature
UnknownUncoupling antisense-mediated silencing and DNA methylation in the imprinted Gnas cluster.
Not available
S-EPMC3063750 | biostudies-literature
UnknownLive-Cell Super-resolution Reveals F-Actin and Plasma Membrane Dynamics at the T Cell Synapse.
Not available
S-EPMC5406376 | biostudies-literature
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