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GenomicsThe Transcriptional Programme Controlled by Scl/Tal1 Gene during Early Embryonic Haematopoietic Development
The basic-helix-loop-helix transcription factor Scl/Tal1 controls the development and subsequent differentiation of haematopoietic stem cells (HSCs). However, since few Scl target genes have been validated to date, the underlying mechanisms have remained largely unknown. Here we have employed ChIP...
ORGANISM(S): Mus musculus 
2009-06-19 | E-GEOD-15806 | biostudies-arrayexpress
GenomicsGenome-wide analysis of GATA1, GATA2, RUNX1, FLI1 and SCL binding in primary human megakaryocytes
We have mapped the binding sites for the five key regulators GATA1, GATA2, RUNX1, FLI1 and TAL1/SCL in primary human megakaryocytes. Statistical analysis identified subsets of enriched as well as depleted combinatorial binding patterns. In particular simultaneous binding by all 5 factors was highly ...
ORGANISM(S): Homo sapiens 
2011-06-01 | E-GEOD-24674 | biostudies-arrayexpress
ProteomicsQuantitative Proteomics Identify a Novel DNA Repair-Dependent Role for Hepatocyte Nuclear Factor 4α
Hepatocyte nuclear factor 4 (HNF4) is a transcription factor that acts as a master regulator of genes in several endodermal-derived tissues, including the intestine in which it plays a central role during development and tumorigenesis. To better delineate the mechanisms by which HNF4 can interfere d...
ORGANISM(S): Homo sapiens (Human) 
2019-11-12 | PXD008365 | Pride
Gfp-trap Colorectal cancer Dna repair Human Silac Hnf4alpha Quantitative proteomics Bioid 
UnknownExperiences of running a stratified medicine adaptive platform trial: Challenges and lessons learned from 10 years of the FOCUS4 trial in metastatic colorectal cancer.
Not available
S-EPMC9036145 | biostudies-literature
UnknownNeural ensemble dynamics in dorsal motor cortex during speech in people with paralysis.
Not available
S-EPMC6954053 | biostudies-literature
UnknownRecombination Suppression Drives Expansion of the Drosophila Dot Chromosome.
Not available
S-EPMC12728734 | biostudies-literature
UnknownMultiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study.
Not available
S-EPMC7615263 | biostudies-literature
UnknownBlood-based protein biomarkers for diagnosis of Alzheimer disease.
Not available
S-EPMC6287606 | biostudies-literature
UnknownUse of Lipid-Lowering Therapies Over 2 Years in GOULD, a Registry of Patients With Atherosclerotic Cardiovascular Disease in the US.
Not available
S-EPMC8209562 | biostudies-literature
UnknownWho, if anyone, may benefit from a total hip arthroplasty after a displaced femoral neck fracture?: a post hoc subgroup analysis of the HEALTH trial.
Not available
S-EPMC9422900 | biostudies-literature
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