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ProteomicsRegulation of stress signaling by SCD1
Cytotoxic stress activates stress-activated kinases, initiates adaptive mechanisms, including the unfolded protein response (UPR) and autophagy, and induces programmed cell death. Fatty acid unsaturation, controlled by stearoyl-CoA desaturase (SCD)1, prevents cytotoxic stress but the mechanisms are ...
ORGANISM(S): Mus musculus (Mouse) 
2022-03-24 | PXD031890 | Pride
Phospholipid Stress signaling Monounsaturated fatty acid Lc-mse Mouse fibroblasts 
ProteomicsProteomic alterations in the context of survival signaling and redox homeostasis linked to de novo fatty acid biosynthesis
Cell death programs like apoptosis, necroptosis, and ferroptosis have an oxidative component linked to lipid metabolism that impacts membrane homeostasis. Evidence for cross-talk between these programs is emerging, highlighting the need for overarching regulatory mechanisms. We investigated changes ...
ORGANISM(S): Mus musculus (Mouse) 
2025-01-04 | PXD053866 | Pride
Programmed cell death Phospholipids Monounsaturated fatty acid Redox homeostasis Mouse fibroblast Cytotoxic stress 
MetabolomicsNontargeted and targeted metabolomics measurements of abiotic stress responses in three-week-old Arabidopsis thaliana plants' rosette leaf tissue
Nontargeted and targeted metabolomics measurements of abiotic stress responses in three-week-old Arabidopsis thaliana plants' rosette leaf tissue for Col-0 wild type plants and double/triple knockout mutants of aquaporins (pip2;1 pip2;2 and pip2;1 pip2;2 pip2;4) treated with drought, heat at differe...
2017-07-17 | MTBLS355 | MetaboLights
UnknownIdentifying Patients without a Survival Benefit following Transfemoral and Transapical Transcatheter Aortic Valve Replacement.
Not available
S-EPMC8584860 | biostudies-literature
TranscriptomicsRoles of relSpn in Stringent Response, Global Regulation, and Virulence of Serotype 2 Streptococcus pneumoniae D39
Transcriptome analysis of D39 rel+Spn and delta-relSpn strains treated with mupirocin revealed relSpn-independent (translation stress), relSpn-dependent (stringent response), and delta-relSpn-dependent changes suggesting that relSpn and (p)ppGpp amount play wide-ranging homeostatic roles in pneumoco...
ORGANISM(S): Streptococcus pneumoniae 
2010-05-15 | E-GEOD-14750 | biostudies-arrayexpress
ProteomicsProteomics of diphtheria toxoid vaccines reveals multiple proteins that are immunogenic and may contribute to protection of humans against Corynebacterium diphtheriae
Introduced for mass immunization in the 1920s, vaccines against diphtheria are among the oldest and safest vaccines known. The basic principle of their production is the inactivation of purified diphtheria toxin by formaldehyde cross-linking, which converts the potentially fatal toxin in a completel...
ORGANISM(S): Corynebacterium diphtheriae NCTC 13129 Clostridium tetani E88 
2019-04-18 | PXD012806 | Pride
Proteomics Mass spectrometry Coryebacteria Exoproteome Vaccination Secretome 
Transcriptomics'Microarray analysis of abiotic stress responses in three-week-old Arabidopsis thaliana plants'' rosette leaf tissue for Col-0 wild type plants and double/triple knockout mutants of aquaporins (pip2;1 pip2;2 and pip2;1 pip2;2 pip2;4) treated with drought, heat at different air humidities, or combined drought-heat stress at different air humidities'
This experiment contains microarray measurements for 135 Arabidopsis thaliana rosette leaf samples covering three genotypes under six different environmental conditions. The three genotypes comprise the Col-0 wildtype and two loss-of-function mutants of aquaporins, a pip2;1 pip2;2 double mutant and ...
ORGANISM(S): Arabidopsis thaliana 
2017-06-20 | E-MTAB-4867 | biostudies-arrayexpress
UnknownThe Iliofemoral tortuosity score predicts access and bleeding complications during transfemoral transcatheter aortic valve replacement: DataData from the VIenna Cardio Thoracic aOrtic valve registrY (VICTORY).
Not available
S-EPMC8243921 | biostudies-literature
UnknownLipoprotein turnover and possible remnant accumulation in preeclampsia: insights from the Freiburg Preeclampsia H.E.L.P.-apheresis study.
Not available
S-EPMC5853053 | biostudies-literature
ProteomicsRegulation of the stress proteome by SCD1
Cytotoxic stress activates stress-activated kinases, initiates adaptive mechanisms, including the unfolded protein response (UPR) and autophagy, and induces programmed cell death. Fatty acid unsaturation prevents cytotoxic stress but the mechanisms are diffuse. We investigated changes in the proteom...
ORGANISM(S): Mus musculus (Mouse) 
2022-04-06 | PXD025396 | Pride
Autophagy Erad Phospholipid Programmed cell death Upr Stress signaling Monounsaturated fatty acid Mouse fibroblast 
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