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TranscriptomicsDeciphering the transcriptional response mediated by the redox-sensing system HbpS-SenS-SenR from streptomycetes
Comparative analyses of the transcriptomes of the Streptomyces coelicolor A3(2) wild-type and the generated hbpSc-senSc-senRc (hsr) mutant under native and oxidative-stressing conditions allowed to identify differentially expressed genes, whose products may enhance the anti-oxidative defense of the ...
ORGANISM(S): Streptomyces coelicolor 
2016-06-30 | E-MTAB-4833 | biostudies-arrayexpress
ProteomicsProteomic characterization of cerebrospinal fluid in patients with brain malignancies
Recent technological advances in molecular diagnostics through liquid biopsies hold the promise to monitor tumor evolution and treatment response of brain malignancies without the need of invasive surgical tissue accrual. Here, we implemented a new mass spectrometry-based protein analysis pipeline a...
ORGANISM(S): Homo sapiens (Human) 
2021-03-25 | PXD021984 | Pride
Brain tumor Glioblastoma Proteome Biomarker 
TranscriptomicsMonitoring global differential gene expression in Corynebacterium glutamicum in response to sigma factor SigD disruption and overexpression
In this study, disruption and overexpression of sigD were performed in Corynebacterium glutamicum and analyzed by transcriptome sequencing (RNA-seq) to understand the SigD regulon in C. glutamicum. For the effect of sigD overexpression, the relative abundance of mRNA was compared in WT(pVWEx1-sigD) ...
ORGANISM(S): Corynebacterium glutamicum ATCC 13032 
2017-01-27 | E-MTAB-5411 | biostudies-arrayexpress
TranscriptomicsMonitoring global differential gene expression in context of protein thiol-oxidation and protein S-mycothiolation in Mycobacterium smegmatis str. MC2 155 under hypochlorite stress.
Mycobacterium smegmatis mc2 155 wild type strain was grown in triplicate in modified Hartmans-de Bont minimal medium (HdB) at 37C and vigorous agitation. Cultures were exposed to 1 mM NaOCl at an optical density at 500 nm (OD500) of 0.4 0.45 in the early log phase. M. smegmatis mc2 155 cells of 3...
ORGANISM(S): Mycobacterium smegmatis str. MC2 155 
2016-03-13 | E-MTAB-4522 | biostudies-arrayexpress
TranscriptomicsThe guanidinobutyrase GbuA is essential for the alkylquinolone-regulated pyocyanin production during parasitic growth of Pseudomonas aeruginosa in co-culture with Aeromonas hydrophila
The opportunistic pathogen Pseudomonas aeruginosa controls the production of virulence factors via its quorum sensing (QS) systems. The addition of 100 M 4-GB to succinate-containing medium led to a strong reduction of pyocyanin production in strain PAO1gbuA, whereas pyocyanin production by the wild...
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2016-06-08 | E-MTAB-4777 | biostudies-arrayexpress
TranscriptomicsDifferential transcriptomic analysis reveals hidden light stress response in Streptomyces lividans TK24
By the direct comparison of illuminated and non-illuminated microtiter plate cultures of Streptomyces lividans TK24 transcriptomes, the effects of differing cultivation systems by the relevance of light, a parameter that is usually out of scope during heterotrophic bioprocesses, could be addressed.
ORGANISM(S): Streptomyces lividans 
2017-05-01 | E-MTAB-5623 | biostudies-arrayexpress
ProteomicsA clinically applicable connectivity signature for glioblastoma includes the tumor network driver CHI3L1
Tumor microtubes (TMs) connect glioma cells to a network with considerable relevance for tumor progression and therapy resistance. The determination of TM-interconnectivity in individual tumors has been challenging and the impact on patient survival unresolved. Here, a connectivity signature from si...
ORGANISM(S): Homo sapiens (Human) 
2023-11-27 | PXD044001 | Pride
Gene expression signature Glioblastoma Connectivity Tumor microtubes Single-cell rna-sequencing 
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