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ProteomicsLabel-free DIA proteomics of WT, HET, and SMA mouse liver at postnatal day 10 (P10)
This dataset contains label-free DIA proteomics of liver tissue from postnatal day 10 (P10) Taiwanese SMA mice (genotype: Smn−/−; SMN2tg/0), heterozygous carriers (HET, Smn+/−; SMN2tg/0), and wild-type controls (WT, Smn+/+; SMN2 0/0). SMA and HET samples were littermates generated from the same F...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-11 | PXD070887 | Pride
P10 Mouse model Proteomics Dia-nn Dia Sma Liver Het Label-free quantification Label-free Wt Spinal muscular atrophy 
TranscriptomicsNeuronal-specific Deficiency of the Splicing Factor Tra2b Causes p21-mediated Apoptosis in Neurogenic Areas of the Developing Mouse Brain
Alternative splicing (AS) increases the informational content of the genome and is more prevalent in the brain than in any other tissue. The splicing factor Tra2b (Sfrs10) can modulate splicing inclusion of exons by specifically detecting GAA-rich binding motifs and its absence causes early embryoni...
ORGANISM(S): Mus musculus 
2013-12-16 | E-MTAB-2157 | biostudies-arrayexpress
TranscriptomicsSuppression of NCALD protects against spinal muscular atrophy by restoring impaired endocytosis
Spinal muscular atrophy (SMA) is a common genetic motor neuron (MN) disease caused by low levels of the ubiquitously expressed housekeeping survival motor neuron (SMN) protein, whereas concomitant overexpression of plastin 3 (PLS3) protects from SMA. Here we identify neurocalcin delta (NCALD), a neu...
ORGANISM(S): Homo sapiens 
2015-01-01 | E-GEOD-58316 | biostudies-arrayexpress
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