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ProteomicsStress-induced changes in the S-palmitoylation and S-nitrosylation of proteins involved in synaptic plasticity
Summary The precise regulation of synaptic integrity is critical for neuronal network connectivity and proper brain function. Essential aspects of the activity and localization of synaptic proteins are regulated by posttranslational modifications. S-palmitoylation is a reversible covalent modificati...
ORGANISM(S): Mus musculus (Mouse) 
2019-07-16 | PXD010822 | Pride
Ptm's interplay Cell signaling Mass spectrometry Postsynaptic density synapse Nitrosylation palmitoylation 
ProteomicsAttenuated palmitoylation of serotonin receptor 5-HT1A in brain affects receptor functions and triggers depressive symptoms
The serotonergic system and in particular serotonin 1A receptor (5-HT1AR) are critically implicated in major depressive disorder (MDD), although underlying mechanisms remain enigmatic. Here we demonstrated that 5-HT1AR is palmitoylated in human and rodent brains and identified ZDHHC21 as a major pa...
ORGANISM(S): Mus musculus (Mouse) 
2019-07-16 | PXD012736 | Pride
Suicide Depression Mirna Zdhhc Palmitoylation Serotonin 5-ht1a receptor 
ProteomicsMolecular mechanism of resilience in stress-related disorders
Stress resilience is a dynamic process whereby an individual can withstand stressful events while still maintaining normal, physiological functioning. Resilience is inferred from an observed level of cognitive performance higher than expected in the face of a demonstrated stressful event. The neural...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD026590 | Pride
Depression Cus model 
ProteomicsDHHC7-mediated palmitoylation of barttin is a risk factor for Bartter syndrome
Chloride permeability in the thin and thick ascending limbs of the loop of Henle is a crucial component for urine concentration, with ClC-K/barttin chloride channels as a central component in establishing the cortico-medullary osmotic gradient. Barttin is an accessory subunit of human ClC-K channels...
ORGANISM(S): Mus musculus (Mouse) 
2020-03-31 | PXD017231 | Pride
Barttin Mass spectrometry Dhhc7 Palmitoylation Bartter syndrome Panimoni 
ProteomicsSynaptic protein S-palmitoylation as a novel mechanism underlying sex-dependent differences in neuronal plasticity
Although sex differences in the brain are prevalent, the knowledge about mechanisms underlying sex-related effects on normal and pathological brain functioning is rather poor. It is known that female and male brains differ in size and connectivity. Moreover, those differences are related to neuronal...
ORGANISM(S): Mus musculus (Mouse) 
2021-06-23 | PXD025286 | Pride
Sex-dependent Dhhc7 Palmitoylation 
UnknownMulticomponent intervention to prevent mobility disability in frail older adults: randomised controlled trial (SPRINTT project).
Not available
S-EPMC9092831 | biostudies-literature
UnknownThe sarcopenia and physical frailty in older people: multi-component treatment strategies (SPRINTT) project: description and feasibility of a nutrition intervention in community-dwelling older Europeans.
Not available
S-EPMC7990826 | biostudies-literature
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