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TranscriptomicsWnt/planar cell polarity primed intestinal stem cells directly differentiate into enteroendocrine or Paneth cells
A detailed understanding of intestinal stem cell (ISC) self-renewal and differentiation is required for better treatment options for a variety of chronic intestinal diseases, however, current models of ISC lineage hierarchy and segregation are still under debate. Here we report the identification of...
ORGANISM(S): Mus musculus 
2020-09-11 | GSE72112 | GEO
TranscriptomicsDissecting the signaling pathways associated with the oncogenic activity of MLK3 P252H mutation
MLK3 gene mutations were described to occur in about 20% of microsatellite unstable gastrointestinal cancers and to harbor oncogenic activity. In particular, mutation P252H, located in the kinase domain, was found to have a strong transforming potential, and to promote the growth of highly invasive ...
ORGANISM(S): Homo sapiens 
2014-03-21 | E-GEOD-54611 | biostudies-arrayexpress
UnknownAtmin modulates Pkhd1 expression and may mediate Autosomal Recessive Polycystic Kidney Disease (ARPKD) through altered non-canonical Wnt/Planar Cell Polarity (PCP) signalling.
Not available
S-EPMC6335440 | biostudies-literature
ProteomicsProximity interactomes of human PRICKLE1, PRICKLE2 and PRICKLE3
Prickle represents an evolutionarily conserved family of proteins that is specifically linked to Wnt/planar cell polarity (PCP) signalling. This signalling pathway is crucial for the correct polarization of epithelial cells along the plane of the epithelial tissue in both Drosophila and vertebrates....
ORGANISM(S): Homo sapiens (Human) 
2026-02-09 | PXD057854 | Pride
Hek293 t-rex Wnt/planar cell polarity (pcp) signalling Prickle Miniturboid 
TranscriptomicsRNA-seq of zebrafish embryos to investigate how Rbm8a deficiency akin to TAR Syndrome causes hematopoietic defects by modulating Wnt/PCP signaling
Defects in blood development are a major contributor to complex congenital anomalies. Thrombocytopenia-Absent Radius (TAR) Syndrome is a rare congenital disease presenting with reduced blood platelets (megakaryocytic thrombocytopenia) and forelimb anomalies, concurrent with variable heart and kidney...
ORGANISM(S): Danio rerio 
2023-03-31 | E-MTAB-12503 | biostudies-arrayexpress
GenomicsMus musculus
Wnt/planar cell polarity primed intestinal stem cells directly differentiate into enteroendocrine or Paneth cells
PRJNA293037 | ENA
TranscriptomicsTranscriptome profiling of e11.25 mouse pancreas: comparison between Ngn3-/- and Ngn3-/- ; Pdx1::Ngn3ER TM pancreatic epithelium
Individual pancreatic buds of crosses between Ngn3+/- and Ngn3+/- ; Pdx1::Ngn3ER TM -IRES-GFP were dissected. Pregnant females were injected intra-peritoneal with 2mg of Tamoxifen at e10.25 (9 am) and dissected at e11.25 (9 to 11 am). Most of the mesenchymal tissue was removed to reduce the tissue c...
ORGANISM(S): Mus musculus 
2014-12-02 | E-MTAB-3139 | biostudies-arrayexpress
UnknownIdentification of p62/SQSTM1 as a component of non-canonical Wnt VANGL2-JNK signalling in breast cancer.
Not available
S-EPMC4729931 | biostudies-literature
UnknownPlanar cell polarity signalling coordinates heart tube remodelling through tissue-scale polarisation of actomyosin activity.
Not available
S-EPMC5986786 | biostudies-literature
TranscriptomicsIdentification of proliferative and mature β-cells in the islet of Langerhans
Insulin-dependent diabetes is a complex multifactorial disorder characterized by loss or dysfunction of β-cells. Pancreatic β-cells differ in size, glucose responsiveness, insulin secretion and precursor cell potential1-5, thus understanding the mechanisms underlying this functional heterogeneity ...
ORGANISM(S): Mus musculus 
2016-06-02 | E-GEOD-68853 | biostudies-arrayexpress
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