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TranscriptomicsComparison of the effects of early pregnancy with human interferon, alpha 2 (IFNA2) on gene expression in bovine endometrium
Interferon tau (IFNT), a Type I IFN similar to alpha IFNs (IFNA), is the pregnancy recognition signal, produced by the ruminant conceptus. To elucidate specific effects of bovine IFNT and of other conceptus-derived factors, endometrial gene expression changes during early pregnancy were compared to ...
ORGANISM(S): Bos taurus 
2011-10-31 | E-GEOD-30694 | biostudies-arrayexpress
TranscriptomicsMessenger RNA profiling of bovine endometrium during the estrous cycle using a custom-made cDNA array
The endometrium provides optimal conditions for the transport of sperm to the oviduct, to the site of fertilization, and later on for the reception of the embryo. To study these changes on the level of gene expression, a messenger RNA expression profiling of endometrium tissue samples collected from...
ORGANISM(S): Bos taurus 
2010-05-27 | E-GEOD-8337 | biostudies-arrayexpress
TranscriptomicsFine mapping of genome activation in bovine embryos by RNA sequencing
During maternal-to-embryonic transition control of embryonic development gradually switches from maternal RNAs and proteins stored in the oocyte to gene products generated after embryonic genome activation (EGA). Detailed insight into the onset of embryonic transcription is obscured by the presence ...
ORGANISM(S): Bos taurus 
2014-02-09 | E-GEOD-52415 | biostudies-arrayexpress
TranscriptomicsBovine endometrium at day 18 of pregnancy after transfer of in vitro produced or somatic cell nuclear transfer embryos
Although somatic cell nuclear transfer (SCNT) cloning is more efficient in bovine than in all other species tested so far, there is a high rate of pregnancy failure that has been linked to structural and functional abnormalities of the placenta. We tested the hypothesis that these changes may origin...
ORGANISM(S): Bos taurus 
2009-03-12 | E-GEOD-13663 | biostudies-arrayexpress
TranscriptomicsDeletion of DMD exon 52 in the pig results in fulminant muscular dystrophy
Duchenne muscular dystrophy (DMD) is caused by mutations in the X-linked dystrophin (DMD) gene. The absence of dystrophin protein leads to progressive muscle weakness and wasting, disability and death. To establish a tailored large animal model of DMD, we deleted DMD exon 52 in male pig cells by gen...
ORGANISM(S): Sus scrofa 
2013-08-06 | E-GEOD-44096 | biostudies-arrayexpress
TranscriptomicsGenome wide screen reveals WNT11, a noncanonical WNT gene, as a target of ETS transcription factor ERG
ERG is a transcription factor that is involved in leukomogenesis and its mRNA overexpression has been associated with poor prognosis in a subset of patients with T-cell acute lymphoblastic leukemia (T-ALL) and acute myeloid leukemia (AML). Herein, a genome-wide screen of ERG target genes was conduct...
ORGANISM(S): Homo sapiens 
2010-12-10 | E-GEOD-21495 | biostudies-arrayexpress
TranscriptomicsStem cell factor Sox2 regulates the tumorigenic potential in human gastric cancer cells
Gastric cancer is still one of the most common causes of cancer-related death worldwide, which is mainly attributable to late diagnosis and poor treatment options. Infection with H. pylori, different environmental factors and genetic alterations are known to influence the risk of developing gastric ...
ORGANISM(S): Homo sapiens 
2013-12-31 | E-GEOD-42937 | biostudies-arrayexpress
TranscriptomicsPharmacodynamic effects of GLP-1 agonist liraglutide in adolescent, prediabetic pigs
GLP-1 agonists are potent glucose-lowering agents, however, their effect on adolescent organisms needs to be clarified Transgenic pigs expressing a dominant-negative GLP receptor randomly assigned for a 90 day treatment trial with liraglutide (0.6-1.8 mg per day)/placebo
ORGANISM(S): Sus scrofa 
2015-12-31 | E-GEOD-56427 | biostudies-arrayexpress
TranscriptomicsBezafibrate improves insulin sensitivity and metabolic flexibility in STZ-treated diabetic mice
Bezafibrate (BEZ), a pan activator of peroxisome proliferator-activated receptors (PPARs), is generally used to treat hyperlipidemia. Clinical trials on patients suffering from type 2 diabetes indicated that BEZ also has beneficial effects on glucose metabolism, but the underlying mechanisms remain ...
ORGANISM(S): Mus musculus 
2016-06-29 | E-GEOD-79008 | biostudies-arrayexpress
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