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ProteomicsEpidermal Stratification Requires Retromer-Mediated Desmoglein-1 Recycling
Sorting transmembrane cargo is essential for tissue development and homeostasis. However, mechanisms of intracellular trafficking in stratified epidermis are poorly understood. Here we identify an interaction between the retromer endosomal trafficking component, VPS35, and the desmosomal cadherin, D...
ORGANISM(S): Homo sapiens (Human) 
2023-07-24 | PXD036646 | Pride
Desmosome  keratinocyte  epidermal differentiation  skin disease  endosomal trafficking  retromer chaperone  vps35  sam syndrome  cadherin  dsg1  glut1  bioid 
ProteomicsBiomarkers of pediatric cataracts: a proteomics analysis of aqueous fluid
Abstract Background: Cataracts are among the most common causes of childhood vision loss worldwide. This study seeks to identify differentially expressed proteins in the aqueous humor of pediatric cataract patients. Methods: Samples of aqueous humor were collected from pediatric and adult cataract...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD022529 | Pride
Q-exactive Pediatric cataracts  proteomics  aqueous humor Lfq 
ProteomicsO-GlcNAcylation enhances double strand break repair, promotes cancer cell proliferation and prevents therapy-induced senescence in irradiated tumors
The metabolic reprogramming associated with characteristic increases in glucose and glutamine metabolism common in advanced cancer is often ascribed to answering a higher demand for metabolic intermediates required for rapid tumor cell growth. Instead, recent discoveries have pointed to an alternati...
ORGANISM(S): Homo sapiens (Human) 
2019-04-30 | PXD010820 | Pride
Hbp pathway Mass spectrometry Dna repair Shoga Lfq quantification Shogt O-glcnacylation Chromatin modification Q-exactive 
ProteomicsPseudomonas syringae effector HopZ3 suppresses PTO immune pathway in tomato by acetylation
The plant pathogen Pseudomonas syringae secretes multiple effectors to suppress plant defenses. Some effectors are recognized by plants while others can function to suppress the resulting immune responses. HopZ3 of Psy B728a is an aminotransferase targeting multiple components of both plant immune ...
ORGANISM(S): Pseudomonas syringae pv. syringae 
2021-10-18 | PXD022953 | Pride
Lc-msms Ptms Q-exactive Pto Hopz3 Plant effectors Acetylation Phosphorylation 
ProteomicsA Novel Method for Isolating Whole Protein from Human Cranial Bone
The presence of the extracellular matrix within human bone limits the applicability of conventional protocols for protein extraction. As a result, complete and accurate characterization of human bone proteome is yet to be performed, and as a result, several bone-related diseases such as craniosynost...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-28 | MSV000080697 | MassIVE
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