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ProteomicsMicroglia display altered spatial morphology and proteome after stroke
Microglia are abundantly distributed throughout the central nervous system (CNS) to play critical roles in neural development and homeostasis, and act as immune sentinels to constantly monitor their surrounding neural environment. Given their high reactivity to brain insults, we hypothesised that th...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-22 | PXD055588 | Pride
Stroke Neuroinflammation Proteome Mouse Morphology Microglia 
TranscriptomicsGlobal gene expression profiles in Oct4-knockdown and Ccna2-knockdown mouse embryos.
Gene regulation at the maternal-embryonic transition in the pre-implantation mouse embryo is not well understood. We knock down Ccna2 to establish proof-of-concept that antisense morpholino oligonucleotides can be used to target specific genes. We applied this strategy to study Oct4 and discovered...
ORGANISM(S): Mus musculus 
2008-12-30 | E-GEOD-13981 | biostudies-arrayexpress
ProteomicsExtracellular vimentin mimics VEGF and is a target for anti-angiogenic immunotherapy
Anti-angiogenic anticancer therapies possess immune-stimulatory properties by counteracting pro-angiogenic molecular mechanisms. We report that tumor endothelial cells ubiquitously overexpress and secrete the intermediate filament protein vimentin through type III unconventional mechanisms. Extracel...
ORGANISM(S): Homo sapiens (Human) 
2022-03-29 | PXD024426 | Pride
Vegf Angiogenesis Human Vimentin Cancer Anti-angiogenic therapy 
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