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The phosphoinositide 3-kinase (PI3K)-Akt network is tightly controlled by feedback mechanisms that regulate signal flow and ensure signal fidelity. Here, we show that Akt itself engages negative feedback by phosphorylating insulin receptor substrate (IRS) 1 and 2 on a number of residues. Mechanistic...
ORGANISM(S): Mus musculus (Mouse) 
2021-07-14 | PXD023441 | Pride
LFQ-MS profiling of hFWE4-positive vesicles and hFWE4-mediated alterations to cell surface proteome in epidermal keratinocytes
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-06-17 | MSV000095056 | MassIVE
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