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ProteomicsThe Inhibitory Receptor Siglec-8 Interacts with FcεRI and Globally Inhibits Intracellular Signaling in Primary Mast Cells Upon Activation
Immunomodulation of mast cell (MC) activity is warranted in allergic and inflammatory diseases where MCs have a central role in pathogenesis. Targeting Siglec-8, an inhibitory receptor on MCs and eosinophils, has shown promising activity in preclinical and clinical studies. While the intracellular p...
ORGANISM(S): Mus musculus (Mouse) 
2022-01-21 | PXD030820 | Pride
Siglec-8 Mast cell 
UnknownA monoclonal antibody to Siglec-8 suppresses non-allergic airway inflammation and inhibits IgE-independent mast cell activation.
Not available
S-EPMC7946634 | biostudies-literature
ProteomicsCodon Specific Readthrough as a Mechanism of BRCA2 Restoration in Acquired PARP Inhibitor and Chemotherapy Resistance
Alteration of the gene encoding BRCA2, a protein involved in homologous recombination (HR), by missense or nonsense mutations results in sensitivity of a subset of breast and ovarian cancers to platinating agents and poly(ADP-ribose) polymerase (PARP) inhibitors. Conversely, resistance to these agen...
ORGANISM(S): Homo sapiens (Human) 
2025-10-27 | PXD037989 | Pride
Translational readthrough Ovarian cancer Brca2 
UnknownA 30-year case study of local implementation of global guidelines for data-driven diabetes management starting with the Hong Kong Diabetes Register.
Not available
S-EPMC11960639 | biostudies-literature
UnknownWound irrigation does not affect health-related quality of life after open fractures: results of a randomized controlled trial.
Not available
S-EPMC6413805 | biostudies-literature
UnknownTpeak-Tend, Tpeak-Tend/QT ratio and Tpeak-Tend dispersion for risk stratification in Brugada Syndrome: A systematic review and meta-analysis.
Not available
S-EPMC6288557 | biostudies-literature
UnknownDeveloping International Consensus on Key Indicators for a 24-Hour Movement Behaviour Report Card in Early Childhood: A Twin-Panel Delphi Study.
Not available
S-EPMC12331558 | biostudies-literature
UnknownImpact of COVID-19 non-pharmaceutical interventions on bacterial infections in children: an international electronic health record-based study.
Not available
S-EPMC12699615 | biostudies-literature
UnknownGWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19.
Not available
S-EPMC10208981 | biostudies-literature
UnknownThe Association of Baseline Plasma SARS-CoV-2 Nucleocapsid Antigen Level and Outcomes in Patients Hospitalized With COVID-19.
Not available
S-EPMC9447373 | biostudies-literature
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