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The survival of children with DIPG remains dismal, with new treatments desperately needed. In the era of precision medicine, targeted therapies represent an exciting treatment opportunity, yet resistance can rapidly emerge, playing an important role in treatment failure. In a prospective biopsy-stra...
ORGANISM(S): Homo sapiens (Human) 
2021-07-20 | PXD019701 | Pride
The goal of the study was to profile the effects of KRAS inhibition in peripheral neuron cells. Phosphoproteomics was performed to profile global changes in phosphorylation after treatment with BI-2865.
ORGANISM(S): Homo sapiens (Human) 
2025-06-17 | PXD061467 | Pride
The haploid and the heterozygous essential S.cerevisiae deletion pools were grown in the presence of compounds that we found to be synergistic with fluconazole. We also treated the deletion pools with combinations of those drugs and fluconazole to interrogate the mechanism of action of the drug inte...
ORGANISM(S): Saccharomyces cerevisiae 
The goal of the study was to profile the effects of MEK inhibition in iPN cells or control sgNTC iPN cells. Phosphoproteomics was performed to profile global changes in phosphorylation after treatment with selumetinib.
ORGANISM(S): Homo sapiens (Human) 
2025-06-17 | PXD064434 | Pride
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