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Metabolomics1H NMR metabolomics and lipidomics analysis of neutrophils reveals biomarkers of ageing, inflammageing and frailty
Neutrophil function declines with age, but little is known about the changes in neutrophil metabolism that take place in robust older people and older people with frailty. We used 1H-NMR spectroscopy to investigate the metabolomic and lipidomic profiles of blood neutrophils from healthy y...
2026-03-26 | MTBLS6055 | MetaboLights
TranscriptomicsTranscription profiling of human lung fibroblasts (HLF) treated with Cr(VI) a carcingogen in the presence of PTP to investigate the effect of protein tyrosine phosphatases inhibition on changes in gene expression
Although the consequences of genotoxic injury include cell cycle arrest and apoptosis, cell survival responses after genotoxic injury can produce intrinsic death-resistance and contribute to the development of a transformed phenotype. Protein tyrosine phosphatases (PTPs) are integral components of k...
ORGANISM(S): Homo sapiens 
2009-01-13 | E-GEOD-12205 | biostudies-arrayexpress
TranscriptomicsRNAseq of A375 melanoma cells and A375 with ARID1A KO in control conditions and treatment with trametinib, vemurafenib or combination
The experiment aimed to study mechanisms of melanoma drug resistance. ARID1A confers resistance to trametinib and therefore RNAseq was collected alongside other omics data for parental A375 likes, and A375 lines with ARID1A KO, in the presence of no drug, trametinib, vemurafenib or their combination
ORGANISM(S): Homo sapiens 
2025-02-18 | E-MTAB-14759 | biostudies-arrayexpress
ProteomicsUbiquitin-mediated modulation of necroptotic effector MLKL
We aimed to identify lysine (K) residues that are endogenously ubiquitylated upon TNF-induced necroptosis. To this end, we used a quantitative mass spectrometry-based approach. Briefly, MDFs were treated with TSZ or left untreated and protein lysates were digested with trypsin into peptides. Ubiquit...
ORGANISM(S): Mus musculus (Mouse) 
2021-04-13 | PXD018857 | Pride
Ubiquitin Tmt Cancer Mlkl Mouse Msms 
UnknownAugmenting Buried in Treasures with in-home uncluttering practice: Pilot study in hoarding disorder.
Not available
S-EPMC7437985 | biostudies-literature
UnknownHumoral and cellular immune responses to Lassa fever virus in Lassa fever survivors and their exposed contacts in Southern Nigeria.
Not available
S-EPMC9790078 | biostudies-literature
UnknownGenome-wide association study identifies genetic variation in neurocan as a susceptibility factor for bipolar disorder.
Not available
S-EPMC3059436 | biostudies-literature
UnknownMeta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight.
Not available
S-EPMC6478731 | biostudies-literature
UnknownCore outcome sets for trials of interventions to prevent and to treat multimorbidity in adults in low and middle-income countries: the COSMOS study.
Not available
S-EPMC11340216 | biostudies-literature
UnknownProspects for observing and localizing gravitational-wave transients with Advanced LIGO, Advanced Virgo and KAGRA.
Not available
S-EPMC5920066 | biostudies-literature
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