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TranscriptomicsscRNA-seq of human fetal lung explants with R-SPONDIN Inhibition and human fetal lung primary tissue
Here, we used single cell RNA-sequencing (scRNA-seq) to profile 13-week post-conception distal human fetal lung explants cultured in an air liquid interface system and treated with an LGR5 ectodomain adenovirus that inhibits R-Spondin function or control adenovirus. A third, non-infected, condition ...
ORGANISM(S): Homo sapiens 
2022-01-01 | E-MTAB-10662 | biostudies-arrayexpress
UnknownMAGI2-AS3 rs7783388 polymorphism contributes to colorectal cancer risk through altering the binding affinity of the transcription factor GR to the MAGI2-AS3 promoter.
Not available
S-EPMC7595890 | biostudies-literature
UnknownPoly-GR repeats associated with ALS/FTD gene <i>C9ORF72</i> impair translation elongation and induce a ribotoxic stress response in neurons.
Not available
S-EPMC11466505 | biostudies-literature
TranscriptomicsIntegration of molecular biology tools to obtain information about abundantly expressed genes in flowers of Oncidium Gower Ramsey
Orchids are commercially important flowers, comprising one of the largest families of plants. Model plants such as Arabidopsis do not contain all plant genes. In this study, several molecular biology tools were integrated to isolate the flower-specific gene promoters of Oncidium Gower Ramsey (GR). A...
ORGANISM(S): Oncidium Gower Ramsey 
2013-01-01 | E-GEOD-26504 | biostudies-arrayexpress
UnknownMolecular dynamics of β-hairpin models of epigenetic recognition motifs.
Not available
S-EPMC3482467 | biostudies-literature
TranscriptomicsTemporal effects of intermittent- and sustained hypoxia on gene expression patterns in rat lungs
Time-course gene expression profiles were obtained from lung tissues of the rats treated with room air, intermittent- (IH) or sustained hypoxia (SH) for 1, 3, 7, 14 and 30 days using CodeLink microarrays. Using a systems biology approach, we observed that two different mechanisms are involved in the...
ORGANISM(S): Rattus norvegicus 
2008-12-17 | E-GEOD-8705 | biostudies-arrayexpress
UnknownLong-Life Lithium-Ion Sulfur Pouch Battery Enabled by Regulating Solvent Molecules and Using Lithiated Graphite Anode.
Not available
S-EPMC10602568 | biostudies-literature
TranscriptomicsSelective enhancement and repression of glucocorticoid receptor signaling by coregulator Hic-5
The glucocorticoid receptor (GR) recruits many coregulators via the well characterized AF2 interaction surface in the GR ligand binding domain, but LIM domain coregulator Hic-5 binds to the relatively uncharacterized tau2 activation domain in the hinge region of GR. Requirement of Hic-5 for glucocor...
ORGANISM(S): Homo sapiens 
2014-03-21 | E-GEOD-46448 | biostudies-arrayexpress
MetabolomicsSarcopenic metabolomic profile reflected a sarcopenic phenotype associated with amino acid and essential fatty acid changes

INTRODUCTION: Although sarcopenia greatly affects health and quality of life in older people, its pathophysiological causes are not fully elucidated. To face this challenge, omics technologies can be used. The metabolome gives a vision of the interaction between the genome and t...

2021-09-29 | MTBLS2679 | MetaboLights
TranscriptomicsRegulatory role of SrrAB two-component system in Staphylococcus epidermidis growth and biofilm formation
Biofilm formation is considered the most important factor involved in pathogenicity of Staphylococcus epidermidis.We investigated the role of two-component signal transduction system (TCS) srrAB, which was up-regulated under micro-aerobic condition, in the growth and biofilm formation of S. epidermi...
ORGANISM(S): Staphylococcus epidermidis 
2014-11-21 | E-GEOD-47101 | biostudies-arrayexpress
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