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ProteomicsChemical cross-linking mass spectrometry (XL-MS) analysis of the ApoE3/TREM2 complex
Apolipoprotein E (APOE) and Triggering Receptor Expressed on Myeloid cells 2 (TREM2) are the two strongest genetic risk factors of late-onset Alzheimer’s disease. ApoE binds to the low-density lipoprotein receptor (LDLR) to facilitate the uptake of ApoE-lipoprotein particles. TREM2 is a cell surface...
ORGANISM(S): Homo sapiens (Human) 
2026-10-27 | PXD079870 | Pride
Xl-ms Apoe3 Trem2 
ProteomicsSoluble TREM2 inhibits secondary nucleation of Aβ fibrillization and enhances cellular uptake of fibrillar Aβ
We used sTREM2 obtained from bacterial expression system to form a complex with Aβ40 fibrils in vitro. This complex was chemically cross-linked using two cross-linkers, BS3 and NHSF.
ORGANISM(S): Escherichia Coli 
2022-01-05 | PXD030722 |
ProteomicsA chaperone-like function of FUS ensures TAZ condensates dynamics and transcriptional activation
The Hippo pathway plays important roles in organ development, tissue homeostasis, and tumor growth, and its downstream effector TAZ is a transcriptional coactivator that promotes target gene expression through the formation of biomolecular condensates. However, the mechanisms that regulate the biop...
ORGANISM(S): Homo Sapiens 
2023-02-17 | PXD040257 |
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