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ProteomicsEffective Enrichment Strategy Using Boronic Acid Functionalized Mesoporous Graphene Silica Composites for Intact Glycopeptide Analysis in Human Serum
The heterogeneity and low abundance of protein glycosylation present challenging barriers to the analysis of intact glycopeptides, which is key to comprehensively understanding the role of glycosylation in an organism. Efficient and specific enrichment of intact glycopeptides could help greatly with...
ORGANISM(S): Human 
2021-04-28 | MSV000087324 | MassIVE
ProteomicsHigh-throughput lysis and proteolytic digestion of tissues using pressure cycling technology for proteomics
we describe a protocol for pressure cycling technology (PCT) assisted tissue sample preparation for high-throughput proteomics
ORGANISM(S): Homo Sapiens Mus Musculus 
2021-12-24 | PXD030645 |
ProteomicsNCI60 proteome by PCT-SWATH - Quantitative Proteome Landscape of the NCI-60 Cancer Cell Lines
We obtained quantitative analysis of the NCI-60 cell panels using pressure cycling technology (PCT) and SWATH-MS. Each cell was analyzed in duplicate. The data were analyzed using a cell line SWATH assay library and OpenSWATH, followed by SWATH-expert refinement.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-07-29 | MSV000085848 | MassIVE
ProteomicsProtein N-glycosylation aberrations and glycoproteomic network alterations in Osteoarthritis and Osteoarthritis with Type 2 diabetes
Whether the relationship between type 2 diabetes mellitus (T2DM) and osteoarthritis (OA) could solely be attributed to the shared risk facts, like obesity, remains controversial. There have been a large number of studies that revealed the critical role of abnormal glycosylation in the pathogenesis o...
ORGANISM(S): Homo 
2021-09-26 | PXD028753 |
ProteomicsEdwardsiella tarda strain EIB 202 lysine acetylation and succinylation
The antibiotics resistance of Edwardsiella tarda is prevailing, seeking a novel antimicrobial strategies extremely urgent. Lysine acylation has been proved to play important role on the bacterial physiological function while its role on bacterial antibiotics resistance mechanism still largely unclea...
ORGANISM(S): Edwardsiella Tarda Eib202 
2022-05-12 | PXD033818 |
ProteomicsARIH1 Signaling Promotes Anti-tumor Immunity by Targeting PD-L1 for Proteasomal Degradation
We find EGFR inhibitors promote PD-L1 ubiquitination and proteasomal degradation following GSK3α-mediated phosphorylation of Ser279/Ser283.
ORGANISM(S): Homo Sapiens 
2021-03-01 | PXD024452 |
ProteomicsProteomic and Metabolomic Characterization of COVID-19 Patient Sera
Early detection and effective treatment of severe COVID-19 patients remain major challenges. Here, we performed proteomic and metabolomic profiling of sera from 46 COVID-19 and 53 control individuals. We then trained a machine learning model using proteomic and metabolomic measurements from a traini...
ORGANISM(S): Severe Acute Respiratory Syndrome Coronavirus 2 (ncbitaxon:2697049) Homo Sapiens (ncbitaxon:9606) 
2020-05-29 | MSV000085507 | MassIVE
ProteomicsProteomic and Metabolomic Characterization of COVID-19 Patient Sera MRMHR
Targeted mass spectrometric assays for the 22 proteins in a second test cohort containing 19 COVID-19 patients
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-05-30 | MSV000085515 | MassIVE
ProteomicsProteomic Dynamics of Breast Cancer Cell Lines Identifies Potential Therapeutic Protein Targets
Treatment and relevant targets for breast cancer (BC) remain limited, especially for triple-negative BC (TNBC). We identified 6091 proteins of 76 human BC cell lines using data-independent acquisition (DIA). Integrating prior multi-omics datasets with our proteomic results, we found that including p...
ORGANISM(S): Homo Sapiens 
2023-07-03 | PXD043471 |
ProteomicsCirculating Exosomes proteome of Colorectal Cancer Based on Rapid DIA-MS
Early screening is essential for the treatment of colorectal cancer (CRC). Concerns are rising regarding liquid biopsy due to its low invasiveness and reproducibility, especially when tissue samples are not available. Recent reports suggest that tumor-specific proteins may be stably expressed in exo...
ORGANISM(S): Homo Sapiens 
2019-10-20 | PXD015921 |
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