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ProteomicsProtein ID of the purified mouse CatSpermasome
Proteomic technology was used to identify the components of CatSper complex.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2021-04-28 | MSV000087325 | MassIVE
UnknownEfficacy and Tolerability of First-Line Cetuximab Plus Leucovorin, Fluorouracil, and Oxaliplatin (FOLFOX-4) Versus FOLFOX-4 in Patients With RAS Wild-Type Metastatic Colorectal Cancer: The Open-Label, Randomized, Phase III TAILOR Trial.
Not available
S-EPMC6324088 | biostudies-literature
ProteomicsS6K1-mediated phosphorylation of PDK1 impairs AKT kinase activity and oncogenic functions
Functioning as a master kinase, 3-phosphoinositide-dependent protein kinase 1 (PDK1) plays a fundamental role in phosphorylating and activating protein kinases A, B and C (AGC) family kinases, including AKT. However, upstream regulation of PDK1 remains largely elusive. Here we report that ribosomal ...
ORGANISM(S): Homo Sapiens 
2021-08-27 | PXD028167 |
Proteomicsthe proteomics of IGFBP6 in endothelial cells (HUVECs)
To unravel the direct mechanism of the anti-inflammatory effects of IGFBP6 in ECs, we analysed HUVECs treated with either adenovirus-Flag-IGFBP6 (Ad-IGFBP6) or control adenovirus (Ad-NC). We precipitated IGFBP6 from overexpressed ECs followed by mass spectrometry.
ORGANISM(S): Homo Sapiens 
2024-05-13 | PXD052204 |
ProteomicsTandem mass tag-based quantitative proteomic analysis reveals proteins involved in hemolytic hyperbilirubinemia-induced brain injury in rats
Hemolytic hyperbilirubinemia-induced brain injury (HHIBI) can cause neonatal death, and survivors often have neurological sequelae, including irreversible motor sensitive and cognitive abnormalities. However, the underlying mechanisms remain elusive. By identifying differentially abundant proteins (...
ORGANISM(S): Rattus Rattus 
2023-04-18 | PXD041604 |
ProteomicsThe proteome of chilli pepper stem during Sclerotium rolfsii Infection
In order to further understand the corresponding mechanism of pepper plants in different infection stages.The blocks of fungal mycelia were inoculated on the soil surface about 2 cm away from the base of stem of the pepper plants at the six-leaf stage. After getting rid of the hyphae on stem surface...
ORGANISM(S): Capsicum Annuum 
2021-10-27 | PXD029372 |
ProteomicsIdentification of TRADD phosphorylation sites
We re-introduced Flag-mTRADD into Tradd-/- MEFs, and identified the phosphorylation sites of TRADD which were induced by TNF and inhibited by TAK1 inhibitor 5Z7 using mass spectrometry. We found that TAK1 could mediate the phosphorylation of multiple sites in TRADD upon TNF stimulation. We next perf...
ORGANISM(S): Homo Sapiens 
2024-10-05 | PXD056588 |
ProteomicsR406 binding site on TAK1 identified by MS
We identified of R406 and its pro-drug R788 for the treatment of cancer by inducing necroptosis.
ORGANISM(S): Homo Sapiens 
2023-08-28 | PXD044897 |
ProteomicsCREB3 suppresses hepatocellular carcinoma progression by depressing AKT signaling through competitively binding with INSR and transcriptionally activating RBM38
CREB3 is suggested to interact with many proteins. We explored the potential binding proteins using co-IP.
ORGANISM(S): Homo Sapiens 
2024-05-27 | PXD052604 |
ProteomicsMouse Testis IP-MS Analysis of TEX44 Interacting Proteins
Through whole-exome sequencing of 800 patients with asthenozoospermia, we identified biallelic TEX44 variants in six individuals, all of whom exhibited defective mitochondrial sheath assembly and impaired sperm motility. Using Tex44 knockout mice, we demonstrated that TEX44 interacts with carnitine ...
ORGANISM(S): Mus Musculus 
2025-02-20 | PXD060989 |
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