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MetabolomicsContributions of the Microbiome-Derived Metabolome for Risk Assessment and Prognostication of Pancreatic Cancer

BACKGROUND Increasing evidence implicates microbiome involvement in the development and progression of pancreatic ductal adenocarcinoma (PDAC). Studies suggest that reflux of gut or oral microbiota can lead to colonization in the pancreas, resulting in dysbiosis that culminates ...

2023-08-09 | MTBLS7260 | MetaboLights
MetabolomicsA polyamine-centric blood-based metabolite panel predictive of poor response to CAR T-cell therapy in large B cell lymphoma

Anti-CD19 chimeric antigen receptor (CAR) T-cell therapy for relapsed or refractory (r/r) large B-cell lymphoma (LBCL) results in durable response in only a subset of patients. MYC overexpression in LBCL tumors is associated with poor response to treatment. We tested whether a MYC-driven polyamin...

2022-10-31 | MTBLS5381 | MetaboLights
ProteomicsMulti-omics analysis of natural aging mouse liver
Multi-omics analysis is relatively rare in aging research and has not been used for aging liver study by now. Here, we performed metabolome, proteome and acetylome with livers of 2-month-old and 18-month-old mice.
ORGANISM(S): Mus Musculus 
2020-03-11 | PXD018003 |
ProteomicsLysine Succinylation in Human Lungs
In this study, we performed LC-MS/MS for global profiling of succinylation in 6 human lungs under normal physiological conditions. Our work will help for further study the function of succinylation modification in various physiology and pathology, as well as the energy metabolism and the regulation ...
ORGANISM(S): Homo Sapiens 
2021-11-02 | PXD029533 |
ProteomicsPhosphoproteome profiling of mouse liver during normal aging
Totally, fourteen two-month-old mice were used in the young group and ten eighteen-month-old mice were used in the old group. Their livers were detached for phosphoproteome analysis.
ORGANISM(S): Mus Musculus 
2021-02-21 | PXD024270 |
ProteomicsMulti-organ proteomic and phosphoproteomic landscape of K18-hACE2 mice infected with SARS-CoV-2
Eight 10-week-old female K18-hACE2 mice were equally divided into control (n = 4) and virus-infected group (n = 4). Mice in the virus-infected group were challenged with 10^5 median tissue culture infective dose (TCID50) of SARS-CoV-2 virus by intranasal inoculation and mice in the control group wer...
ORGANISM(S): Mus Musculus 
2022-07-21 | PXD035474 |
ProteomicsGlobal lysine crotonylation profiling in the livers of mice
Crotonylation (Cr) is a novel post-transcriptional modification with the potential to regulate multiple biological processes. In order to improve the crotonylation dataset for further study, we performed LC-MS/MS with mouse liver samples to obtain the in vivo crotonylome. Totally, we identified 4607...
ORGANISM(S): Mus Musculus 
2020-01-19 | PXD015645 |
ProteomicsGlobal lysine crotonylation profiling of mouse liver (label-free quantitative proteomic data)
Crotonylation (Cr) is a novel post-translational modification with the potential to regulate multiple biological processes. To improve the crotonylation dataset for further study, we performed label-free LC-MS/MS with mouse liver samples to obtain an in vivo crotonylome. In this study, 11,408 croton...
ORGANISM(S): Mus Musculus 
2020-05-13 | PXD019145 |
ProteomicsProteomic and phosphoproteomic profiling of COVID-19-associated lung injury: a report based on rhesus macaques
Lung is the major organ affected by SARS-CoV-2. To explore the molecular mechanism in the lung after SARS-CoV-2 infection, we performed LC-MS based proteome and phosphoproteome analysis using lung tissue samples separated from rhesus macaques.
ORGANISM(S): Macaca Mulatta 
2021-07-08 | PXD027180 |
ProteomicsProteomic and phosphoproteomic profiling of COVID-19-associated liver injury: a report based on rhesus macaques
Almost 50% of COVID-19 patients have symptoms of liver injury. To explore the molecular mechanism in the livers after SARS-CoV-2 infection, we performed LC-MS based proteome and phosphoproteme analysis using liver tissue samples separated from rhesus macaques.
ORGANISM(S): Macaca Mulatta 
2021-07-08 | PXD027179 |
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