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ProteomicsUbiquitome profiling reveals metabolism related cell senescence and protein translation modified by UPL3
The HECT domain-containing UPL3 ligase plays critical roles in plant development and stress protection, but its mechanism of action remains unclear. To identify its targets in Arabidopsis thaliana, we conducted proteomic analyses of enriched ubiquitinated proteins in upl3 mutants via label-free mass...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2022-10-14 | PXD027037 | Pride
Hect-type ubiquitin ligase Histone Dubs Carbon fixation Senescence 
UnknownNordic hamstring exercises in functional knee rehabilitation after anterior cruciate ligament reconstruction: a prospective, randomised, controlled study.
Not available
S-EPMC10624851 | biostudies-literature
ProteomicsActive DNA Demethylation by DNMT3A and DNMT3B - Mechanistic Aspect and In Vivo Evidence
The DNA methylation program is at the bottom layer of the epigenetic regulatory cascade of vertebrate development. While the methylation at C-5 position of the cytosine (C) residues on the vertebrate genomes is achieved through the catalytic activities of the DNA methyltransferases (DNMTs), the...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-24 | PXD003401 | Pride
Methylation Lc-msms 
MetabolomicsAnti-anemia drug FG4592 retards the AKI to CKD transition by improving vascular regeneration and anti-oxidative capability (day 21)

Acute kidney injury (AKI) is a known risk factor for the development of chronic kidney disease (CKD), with no satisfactory strategy to prevent the progression of AKI to CKD. Damage to the renal vascular system and subsequent hypoxia are common contributors to both AKI and CKD. Hypoxia inducible f...

2021-07-22 | MTBLS3003 | MetaboLights
MetabolomicsAnti-anemia drug FG4592 retards the AKI to CKD transition by improving vascular regeneration and anti-oxidative capability (day 10)

Acute kidney injury (AKI) is a known risk factor for the development of chronic kidney disease (CKD), with no satisfactory strategy to prevent the progression of AKI to CKD. Damage to the renal vascular system and subsequent hypoxia are common contributors to both AKI and CKD. Hypoxia inducible f...

2021-07-22 | MTBLS3056 | MetaboLights
MetabolomicsUPLC-QTOF-MS-Based Plasma Lipidomic Profiling Reveals Biomarkers for Inflammatory Bowel Disease Diagnosis
Identification of new biomarkers may help in the early diagnosis of inflammatory bowel disease (IBD). In this study, ultrahigh-performance liquid chromatography equipped with quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS) was used to analyze the untargeted lipidomics and compare plasma l...
2021-10-18 | MTBLS1183 | MetaboLights
UnknownDiscovery of fossil lamprey larva from the Lower Cretaceous reveals its three-phased life cycle.
Not available
S-EPMC4217442 | biostudies-literature
ProteomicsStudy physiological and biochemical response of Phaeocystis antarctica to different irradiance and manganese/ iron deficiency
Iron and light are typically recognized as major limiting factors controlling phytoplankton growth in the Southern Ocean. Recent field-based evidence suggests, however, that manganese concentrations in this region can be low enough to impact phytoplankton physiology and primary productivity. Our stu...
ORGANISM(S): Phaeocystis antarctica 
2019-06-25 | PXD010974 | Pride
Manganese Photosynthesis Deprivation Phaeocystis antarctica Proteomic Iron 
MetabolomicsCD73 inhibitor AB680 suppresses glioblastoma in mice by inhibiting purine metabolism and promoting P2RY12<sup>+</sup> microglia transformation.
CD73 (ecto-5'-nucleotidase) is a metabolic immune checkpoint that dephosphorylates AMP to produce adenosine. Adenosine plays a pivotal role in immunosuppressive tumor microenvironment (TME) through adenosine receptors expressed on various immune cells. AB680, a specific CD73 inhibitor, is currently ...
2025-08-04 | MTBLS11084 | MetaboLights
UnknownFossil climbing perch and associated plant megafossils indicate a warm and wet central Tibet during the late Oligocene.
Not available
S-EPMC5429824 | biostudies-literature
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