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Proteomicsmouse CD4+ T cells IP-MS - Reversing SKI-SMAD4-mediated suppression is essential for TH17 cell differentiation
Identifying Smad4-binding proteins in mouse CD4+ T cells under IL6SB condition. Mouse CD4+ T cells were isolated from mouse spleen and lymph nodes.
ORGANISM(S): Mus musculus (Mouse) 
2017-10-26 | PXD007172 | Pride
Mouse Ip-ms Cd4+ t cells 
ProteomicsBlocking CXCR4+ CD4+ T cells reprograms Treg-mediated immunosuppression via modulating the Rho-GTPase/NF-κB pathway
Clinical trials have demonstrated that CXCR4 antagonists enhance the efficacy of immunotherapy in cancers by reducing regulatory T (Treg) cells, elucidating how certain mechanisms of CXCR4 in affecting Treg cells are essential for developing immunotherapeutic strategies.
ORGANISM(S): Homo Sapiens 
2024-11-25 | PXD058262 |
ProteomicsComparative cell surface proteomic analysis of the primary human T cell and monocyte responses to type I interferon
The cellular response to interferon (IFN) is essential for antiviral immunity, IFN-based therapy and IFN-related disease. The plasma membrane (PM) provides a critical interface between the cell and its environment, and is the initial portal of entry for viruses. Nonetheless, the effect of IFN on PM ...
ORGANISM(S): Homo sapiens (Human) 
2021-02-09 | PXD022834 | Pride
T cell Leukocytes Cell surface Antiviral restriction Monocyte Quantitative proteomics Interferon type i (ifn) Plasma membrane 
ProteomicsLabel-free proteome analysis of small extracellular vesicles (sEV) expressing different HRS mutants.
Label-free proteome analysis of small extracellular vesicles (sEV) derived from WM9 cells expressing different HRS mutants: wild type (HRSWT), phospho-deficient (HRSS345A), and phospho-mimetic mutant HRS (HRSS345D).
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-02-16 | MSV000088846 | MassIVE
UnknownFibrillarin Contributes to the Oncogenic Characteristics of Colorectal Cancer Cells and Reduces Sensitivity to 5-Fluorouracil.
Not available
S-EPMC12730408 | biostudies-literature
Proteomicsp-FADD-CD8+T cell axis determines hepatocellular carcinoma response to immune checkpoint inhibitors
The heterogenicity of hepatocellular carcinoma (HCC) remains a key obstacle in turning the majority of ‘immune-cold’ tumors ‘hot’ for effective immune checkpoint inhibitors (ICIs). Through analyzing the naturally-existed ‘hot’ HCC variants, we identified fas-associated death domain (FADD) as a key m...
ORGANISM(S): Homo sapiens (Human) 
2025-07-07 | PXD057519 | Pride
Hcc Fadd Hepg2 
UnknownSemaphorin 6D regulates the late phase of CD4+ T cell primary immune responses.
Not available
S-EPMC2529027 | biostudies-literature
UnknownTranscriptome analysis of the endangered Notopterygium incisum: Cold-tolerance gene discovery and identification of EST-SSR and SNP markers.
Not available
S-EPMC6412102 | biostudies-literature
UnknownCharacterization of Stimulatory Action on Voltage-Gated Na+ Currents Caused by Omecamtiv Mecarbil, Known to Be a Myosin Activator.
Not available
S-EPMC10216194 | biostudies-literature
ProteomicsCell-Surface Proteomic Profiling in the Fly Brain Uncovers New Wiring Regulators
Li J, Han S, Li H, Udeshi ND, Svinkina T, Mani DR, Xu C, Guajardo R, Xie Q, Li T, Luginbuhl DJ, Wu B, McLaughlin CN, Xie A, Kaewsapsak P, Quake sR, Carr SA, Ting AY, Luo L. 2019. Molecular interactions at the cellular interface mediate organized assembly of single cells into tissues, and thus govern...
ORGANISM(S): Drosophila <fruit Fly, Genus> (ncbitaxon:7215) 
2019-11-06 | MSV000084543 | MassIVE
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