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UnknownEvaluation of individual and ensemble probabilistic forecasts of COVID-19 mortality in the United States.
Short-term probabilistic forecasts of the trajectory of the COVID-19 pandemic in the United States have served as a visible and important communication channel between the scientific modeling community and both the general public and decision-makers. Forecasting models provide specific, quantitative...
S-EPMC9169655 | biostudies-literature
TranscriptomicsGene Expression Profiles of Head and Neck Squamous Cell Carcinoma (HNSCC) primary tumors
60 fresh frozen HNSCC from the University of North Carolina at Chapel Hill (UNC) were obtained from the UNC Tissue Procurement Facility under an IRB approved protocol. 55 tumor samples were collected from the primary tumor and five tumor samples were collected from a local recurrence at the primary ...
ORGANISM(S): Homo sapiens 
2010-06-09 | E-GEOD-686 | biostudies-arrayexpress
GenomicsIntra-tumor heterogeneity of localized lung adenocarcinomas defined by multi-region sequencing
Background: Intra-tumor heterogeneity (ITH) may have profound impacts on biopsy strategy, characterization of actionable targets, treatment planning, and drug resistance. ITH of lung cancers has not been well studied. Methods: We performed multi-region whole exome sequencing (average sequencing de...
EGAS00001000930 | EGA
UnknownExcess deaths in people with cardiovascular diseases during the COVID-19 pandemic.

Aims

Cardiovascular diseases (CVDs) increase mortality risk from coronavirus infection (COVID-19). There are also concerns that the pandemic has affected supply and demand of acute cardiovascular care. We estimated excess mortality in specific CVDs, both 'direct', through infection, and 'ind...
S-EPMC7928969 | biostudies-literature
UnknownGenomic heterogeneity of multiple synchronous lung cancer.
Multiple synchronous lung cancers (MSLCs) present a clinical dilemma as to whether individual tumours represent intrapulmonary metastases or independent tumours. In this study we analyse genomic profiles of 15 lung adenocarcinomas and one regional lymph node metastasis from 6 patients with MSLC. All...
S-EPMC5078731 | biostudies-literature
TranscriptomicsSkeletal Muscle Contraction Reduces Effects of Unloading on Bone Independently from the Central Nervous System: Studies Using Functional Electrical Stimulation after Spinal Cord Transection
Spinal cord injury (SCI) causes severe bone loss and disrupts connections between higher centers in the central nervous system (CNS) and bone. Muscle contraction elicited by functional electrical stimulation (FES) partially protects against loss of bone but cellular and molecular events by which th...
ORGANISM(S): Rattus norvegicus 
2012-06-27 | E-GEOD-30301 | biostudies-arrayexpress
UnknownResults of the two incidence screenings in the National Lung Screening Trial.

Background

The National Lung Screening Trial was conducted to determine whether three annual screenings (rounds T0, T1, and T2) with low-dose helical computed tomography (CT), as compared with chest radiography, could reduce mortality from lung cancer. We present detailed findings from the f...
S-EPMC4307922 | biostudies-literature
UnknownComprehensive genomic characterization of head and neck squamous cell carcinomas.
The Cancer Genome Atlas profiled 279 head and neck squamous cell carcinomas (HNSCCs) to provide a comprehensive landscape of somatic genomic alterations. Here we show that human-papillomavirus-associated tumours are dominated by helical domain mutations of the oncogene PIK3CA, novel alterations invo...
S-EPMC4311405 | biostudies-literature
UnknownReduced lung-cancer mortality with low-dose computed tomographic screening.

Background

The aggressive and heterogeneous nature of lung cancer has thwarted efforts to reduce mortality from this cancer through the use of screening. The advent of low-dose helical computed tomography (CT) altered the landscape of lung-cancer screening, with studies indicating that low-d...
S-EPMC4356534 | biostudies-literature
UnknownThe National Lung Screening Trial: overview and study design.
The National Lung Screening Trial (NLST) is a randomized multicenter study comparing low-dose helical computed tomography (CT) with chest radiography in the screening of older current and former heavy smokers for early detection of lung cancer, which is the leading cause of cancer-related death in t...
S-EPMC3009383 | biostudies-literature
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