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Qi2013 - IL-6 and IFN crosstalk model This model [BIOMD0000000544] describes the crosstalk between IFN-gamma and IL-6 induced signalling; it aims to outline mechanisms and factors that may control the interaction between both signalling pathways, discussing a role of heterodimer formation in signa...
2024-09-02 | BIOMD0000000544 | BioModels
Qi2013 - IL-6 and IFN crosstalk model (non-competitive) This model [BIOMD0000000543] describes the crosstalk between IFN-gamma and IL-6 induced signalling; it aims to outline mechanisms and factors that may control the interaction between both signalling pathways, discussing a role of heterodimer f...
2024-09-02 | BIOMD0000000543 | BioModels
The outbreak of coronavirus disease 2019 (COVID-19) is a global health emergency. Various omics results have been reported for COVID-19, but the molecular hallmarks of COVID-19, especially in those patients without comorbidities, have not been fully investigated. Here we collect blood samples from 2...
2021-10-06 | MTBLS2542 | MetaboLights
The molecular explanation for tamoxifen serving as a breast cancer treatment but displaying partial estrogenic in the uterus is not known. Previously, we reported that differential promoter context and cofactor recruitment contribute to the tissue specificity of tamoxifen. Here, we investigated the ...
ORGANISM(S): Homo sapiens 
we propagate norfloxacin-resistant strain, LTB4-R, through sequential propagations of norfloxacin-sensitive LTB4 in TSB broth medium with norfloxacin. LTB4-R had 128-fold minimum inhibitory concentrations (MIC) of LTB4-S. To profile the differential protein expression between LTB4-R and LTB4-S, tand...
ORGANISM(S): Edwardsiella Tarda 
Cyclooxygenase-2 (COX-2) is upregulated in pancreatic ductal adenocarcinomas (PDAC). However, how COX-2 promotes PDAC development is unclear. While previous studies have evaluated the efficacy of COX-2 inhibition via the use of non steroidal anti-inflammatory drugs (NSAIDs) or the COX-2 inhibitor ce...
ORGANISM(S): Mus musculus 
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